Randall P Mccoy

US Patent:

6495120, Dec 17, 2002

Filed:

Aug 30, 2001

Appl. No.:

09/944492

Inventors:

Randall McCoy - Little Falls NJ 08551

International Classification:

A61K 912

US Classification:

424 45, 424 43, 514 2, 514 3, 514 4

Abstract:

A stable formulation is disclosed that enables the effective intra-oral delivery to a patient of a pharmaceutical agent. The formulation comprises the pharmaceutical agent mixed with an orally-acceptable oral-absorption enhancer in an orally-acceptable carrier-solvent, wherein the oral-absorption enhancer is adapted to modify the surface membrane such that absorption through the surface membrane is initiated or increased. The oral-absorption enhancer may comprise hydroxypropyl-beta-cyclodextrin and surfactants including benzalkonium chloride, benzethonium chloride, polysorbate 80, sodium lauryl sulfate, Brij surfactants, Tween and Pluronic surfactants. Also disclosed is a system for delivering the formulation including a mechanism for dispensing predetermined doses of the inventive formulation intra-orally as with an aerosol or spray pump or propellant device.

US Patent:

6531112, Mar 11, 2003

Filed:

May 14, 2001

Appl. No.:

09/855175

Inventors:

Randall E. McCoy - Little Falls NJ

Assignee:

DelRx Pharmaceutical Corporation - Jamesburg NJ

International Classification:

A61K 912

US Classification:

424 46, 424 45, 424434, 424435, 424489, 514 4, 514 9, 12820014

Abstract:

The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed with a permeation enhancer and excipients which are dispersed in a media for oral or intranasal administration. Also provided in the present invention is a process to prepare the formulations.