Randy William Allen

US Patent:

20030054424, Mar 20, 2003

Filed:

Mar 27, 2002

Appl. No.:

10/107867

Inventors:

Randy Allen - Apex NC, US
Thomas Stewart - Durham NC, US

International Classification:

G01N033/53
G01N033/537
G01N033/543

US Classification:

435/007920, 435/007100

Abstract:

Immunoassay methods and standards are provided for determining the presence of polychlorinated biphenyl compounds, in a sample of interest: (a) extracting PCB compounds from the sample into a nonpolar solvent that will dissolve the PCB, to produce an analyte extract, (b) contacting the analyte extract with an mAB with specific reactivity towards PCB compounds under conditions suitable for the monoclonal antibody to bind to the PCBs present in the sample, (c) measuring mAB that is selectively bound to PCB compounds and congeners thereof, to provide a binding level, (d) relating the binding level of the mAB of step (c) with binding levels of the same mAB with a control composition, wherein the control composition comprises a plurality of PCB of compounds of known concentration, and then determining concentrations of PCB compounds in the sample.

US Patent:

20040259096, Dec 23, 2004

Filed:

Aug 6, 2004

Appl. No.:

10/494159

Inventors:

Randy Allen - Apex NC, US
John Willey - Raleigh NC, US

International Classification:

C12Q001/68
C12P019/34

US Classification:

435/006000, 435/091200

Abstract:

The present invention provides rapid, sensitive, consistent and economical methods and assays for measuring analytes and transcription factor activity based on amplification of a nucleic acid-tracer and the subsequent measurement of amplified product that is ultimately correlated with the presence of analyte or transcription factor activity.

US Patent:

20230056380, Feb 23, 2023

Filed:

Mar 31, 2021

Appl. No.:

17/795264

Inventors:

Randy Leiman Allen - Apex NC, US

International Classification:

A61K 49/00

Abstract:

The present invention provides for a kit and methods that detect certain analytes of interest potentially present in blood and bodily fluids of a living mammal. The methods and kit encompass a bioassay performed in vivo. Contact of the bioassay reagent with the analyte, if present, renders a response that can be clinically assessed visually or by reading instrumentation or by biosensor. In one embodiment, the invention may be used to detect the presence, absence, or amount of suspected analyte present in a patient test subject. The invention is particularly suited for point-of-care (POC) use, self-testing, large-scale implementation and for use with patients where limited sample volumes are available or accessible.