George S. Sheppard - Wilmette IL, US Gary T. Wang - Libertyville IL, US Fabio Palazzo - Libertyville IL, US Randy L Bell - Lindenhurst IL, US Robert A. Mantei - Franklin WI, US Jieyi Wang - Lake Bluff IL, US Robert D. Hubbard - Lindenhurst IL, US Megumi Kawai - Libertyville IL, US Scott A. Erickson - Zion IL, US Nwe BaMaung - Niles IL, US Steve D. Fidanze - Grayslake IL, US
Compounds of formula (25) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Nwe Y. Ba-Maung - Niles IL, US Randy L. Bell - Lindenhurst IL, US Richard F. Clark - Gurnee IL, US Scott A. Erickson - Zion IL, US Steve D. Fidanze - Grayslake IL, US Robert D. Hubbard - Lindenhurst IL, US Robert A. Mantei - Franklin WI, US George S. Sheppard - Wilmette IL, US Bryan K. Sorensen - Antioch IL, US Gary T. Wang - Libertyville IL, US Jieyi Wang - Lake Bluff IL, US
Gary T. Wang - Libertyville IL, US Robert A. Mantei - Franklin WI, US Scott A. Erickson - Zion IL, US Steve D. Fidanze - Grayslake IL, US George S. Sheppard - Wilmette IL, US Jieyi Wang - Lake Bluff IL, US Randy L. Bell - Lindenhurst IL, US
Clint D. W. Brooks - Libertyville IL Andrew O. Stewart - Libertyville IL Anwer Basha - Lake Forest IL Randy L. Bell - Lindenhurst IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 31405 C07D20914
US Classification:
514414
Abstract:
Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B. sub. 4, C. sub. 4, D. sub. 4, and E. sub. 4 and cylooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states. The compounds have the structure indicated above wherein A is selected from (a) optinally substituted carbocyclic aryl, (b) optinally substituted furyl, (c) optinally substituted benzo[b]furyl, (d) optinally substituted thienyl, (e) optinally substituted pyridyloxy, (f) optinally substituted pyridylalkyl, (g) optinally substituted benzo[b]thienyl, (h) optinally substituted pyridyl, (i) optinally substituted quinolyl, and (j) optinally substituted indolyl; X is selected from (a) optionally substituted alkyl, (b) optinally substituted alkenyl, and (c) optinally substituted alkynyl; R. sup. 1 and R. sup. 2 are independently selected from hydrogen, hydroxy, and alkyl; and Z is a residue of a non-steroidal anti-inflammatory drug of the general formula Z--COOH.
James G. Montagnino - St. Charles IL Anson Wong - Glendale Heights IL Ricardo Murguia - Berwyn IL Monique Chatterjee - Chicago IL Elliott Hsu - Chicago IL Greg Holderfield - Chicago IL Randy Bell - River Forest IL Dan Peterson - Chicago IL
James G. Montagnino - St. Charles IL Anson Wong - Glendale Heights IL Ricardo Murguia - Berwyn IL Monique Chatterjee - Chicago IL Elliott Hsu - Chicago IL Greg Holderfield - Chicago IL Randy Bell - River Forest IL Dan Peterson - Chicago IL
James G. Montagnino - St. Charles IL Anson Wong - Glendale Heights IL Ricardo Murguia - Berwyn IL Monique Chatterjee - Chicago IL Elliott Hsu - Chicago IL Greg Holderfield - Chicago IL Randy Bell - River Forest IL Dan Peterson - Chicago IL
James G. Montagnino - St. Charles IL Anson Wong - Glendale Heights IL Ricardo Murguia - Berwyn IL Monique Chatterjee - Chicago IL Elliott Hsu - Chicago IL Greg Holderfield - Chicago IL Randy Bell - River Forest IL Dan Peterson - Chicago IL
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