Randy Lynn Jirtle

US Patent:

20110014607, Jan 20, 2011

Filed:

Dec 6, 2007

Appl. No.:

12/517952

Inventors:

Randy L. Jirtle - Durham NC, US
Alexander J. Hartemink - Durham NC, US
Philippe P. Luedi - Basel, CH

International Classification:

C12Q 1/68
G06F 19/00
G06F 15/18

US Classification:

435 6, 702 19, 706 12

Abstract:

Methods for identifying imprinted genes. In some embodiments, the methods comprise (a) providing a first data set comprising a plurality of nucleic acid sequences, wherein the nucleic acid sequences comprise genomic DNA sequences corresponding to a plurality of genes known to be imprinted in the subject; (b) providing a second data set comprising a plurality of nucleic acid sequences, wherein the nucleic acid sequences comprise genomic DNA sequences corresponding to a plurality of genes known not to be imprinted in the subject; (c) identifying one or more features that by themselves or in combination are differentially present or absent from the first data set as compared to the second data set; and (d) applying the one or more features to a test data set comprising a plurality of genomic DNA sequences which correspond to one or more genes for which the imprinting status is unknown to thereby identify an imprinted gene in a subject. The presently disclosed subject matter also provides methods for identifying a feature in a subject with respect to an imprinted gene and methods for detecting a presence of or a susceptibility to a medical condition associated with parent-of-origin dependent monoallelic expression in a subject.

US Patent:

62181270, Apr 17, 2001

Filed:

Mar 17, 2000

Appl. No.:

9/527443

Inventors:

Randy L. Jirtle - Durham NC
Timothy A. Jamieson - Durham NC
J. Keith Killian - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

C12Q 168
C12P 1934
C07H 2104

US Classification:

435 6

Abstract:

The present invention relates, in general, to cancer prognosis and, in particular, to a method of assessing the prognosis of a patent using the M6P/IGF-II receptor.

US Patent:

58742220, Feb 23, 1999

Filed:

Nov 15, 1996

Appl. No.:

8/749852

Inventors:

Randy L. Jirtle - Durham NC
Angus T. DeSouza - London, GB2
Gerald R. Hankins - Charlottesville VA

Assignee:

Duke University - Durham NC
Zeneca Limited - London

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

The present invention relates, in general, to a tumor suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.