Randy James Nelson

US Patent:

20140067021, Mar 6, 2014

Filed:

Aug 27, 2013

Appl. No.:

14/011133

Inventors:

Randy J. Nelson - Dublin OH, US
Zachary M. Weil - Columbus OH, US

Assignee:

Ohio State Innovation Foundation - Columbus OH

International Classification:

A61N 1/36

US Classification:

607 62, 607115

Abstract:

One aspect of the present disclosure relates to a method for treating a circadian rhythm disorder in a mammal. One step of the method includes placing a therapy delivery device into electrical communication with an autonomic nervous system (ANS) nerve target associated with the circadian rhythm disorder. Next, the therapy delivery device is activated to deliver a therapy signal to the ANS nerve target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the mammal and thereby treat the circadian rhythm disorder.

US Patent:

20160045740, Feb 18, 2016

Filed:

Sep 10, 2015

Appl. No.:

14/850192

Inventors:

- Columbus OH, US
Randy J. Nelson - Dublin OH, US
Zachary M. Weil - Columbus OH, US

International Classification:

A61N 1/36
A61N 1/05

Abstract:

One aspect of the present disclosure relates to a closed loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing can be configured to detect at least one physiological parameter associated with PTSD. The delivery component can be configured for implantation on or about a pre-determined spinal simulation site. The pre-determined spinal stimulation site can include a spinal cord segment, or spinal nervous tissue associated therewith, other than a C1-C3 spinal cord segment or spinal nervous tissue associated therewith. The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component to modulate activity at the pre-determined spinal stimulation site to effectively treat PTSD in the subject.

US Patent:

20150374994, Dec 31, 2015

Filed:

Sep 10, 2015

Appl. No.:

14/850155

Inventors:

- Columbus OH, US
Randy J. Nelson - Dublin OH, US
Zachary M. Weil - Columbus OH, US

International Classification:

A61N 1/36
A61N 1/05
A61N 2/00

Abstract:

One aspect of the present disclosure relates to a closed-loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing component can be configured to detect at least one physiological parameter associated with PTSD. The delivery component can be configured for implementation on or about a ganglion of the sympathetic nervous system (SNS). The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component so that activity of the ganglion of the SNS is substantially blocked without enhancing a symptom of PTSD.

US Patent:

20140358451, Dec 4, 2014

Filed:

Jun 4, 2014

Appl. No.:

14/295823

Inventors:

Sai Buddi - Tempe AZ, US
Thomas Taylor - Tempe AZ, US
Randy Nelson - Phoenix AZ, US
Chad Borges - Avondale AZ, US
Douglas Cochran - Phoenix AZ, US

Assignee:

ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY - Scottsdale AZ

International Classification:

G01N 33/68
G06F 19/00
G06F 19/10

US Classification:

702 28

Abstract:

Methods and systems for detecting and quantifying signal peaks from ESI-TOF-MS data may include creating a signal model and a noise model for mass spectrometry (MS) data. The method may also include detecting a signal peak based, at least in part, on the signal model and the noise model for the MS data. The method may further include determining an amplitude of the detected signal peak based, at least in part, on the signal model and the noise model for the MS data.