Randy N Rosier

US Patent:

8513193, Aug 20, 2013

Filed:

Oct 13, 2009

Appl. No.:

13/124002

Inventors:

Randy N. Rosier - Rochester NY, US
Michael J. Zuscik - North Chili NY, US
Erik Sampson - Rochester NY, US
Susan V. Bukata - Pittsford NY, US
J. Edward Puzas - Pittsford NY, US
Hani Awad - Rochester NY, US

Assignee:

University of Rochester - Rochester NY

International Classification:

A61K 39/29
A61K 38/00
A61K 38/16

US Classification:

514 118, 514 171, 514 213

Abstract:

Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular components thereof with a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor agonist or releasing factor.

US Patent:

20090227503, Sep 10, 2009

Filed:

Feb 9, 2009

Appl. No.:

12/368251

Inventors:

Hani A. Awad - Rochester NY, US
Edward M. Schwarz - Rochester NY, US
Susan Bukata - Pittsford NY, US
J. Edward Puzas - Pittsford NY, US
Regis J. O'Keefe - Rochester NY, US
Randy Rosier - Rochester NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 38/29
A61P 19/00

US Classification:

514 12

Abstract:

Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently providing said subject with parathyroid hormone (PTH); where the PTH is provided in an amount effective to enhance in or adjacent to a bone allograft, relative to a patient not provided the PTH, at least one of callus bone volume, callus mineral content, callus bridging, graft stiffness, graft incorporation, and graft resistance to an applied torque.

US Patent:

20140066376, Mar 6, 2014

Filed:

Aug 20, 2013

Appl. No.:

13/971366

Inventors:

Randy N. Rosier - Rochester NY, US
Michael J. Zuscik - North Chili NY, US
Erik Sampson - Rochester NY, US
Susan V. Bukata - Pittsford NY, US
J. Edward Puzas - Pittsford NY, US
Hani Awad - Rochester NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 38/29

US Classification:

514 118, 514 213, 514 171

Abstract:

Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular components thereof with a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor agonist or releasing factor.

US Patent:

60107111, Jan 4, 2000

Filed:

Jan 26, 1996

Appl. No.:

8/592123

Inventors:

Regis James O'Keefe - Pittsford NY
Randy Nathan Rosier - Pittsford NY

Assignee:

University of Rochester - Rochester NY

International Classification:

A61F 228
A61F 200

US Classification:

424423

Abstract:

A class of active agents, and articles and compositions containing them and methods for treating human patients with them, which inhibit bone resorption of all types. This class of active agents comprises phosphodiester inhibiting compositions which inhibit any of interleukin 1 (IL1), interleukin 6 (IL6) and tumor necrosis factor alpha (TNF), which are cytokines that mediate bone resorption. Exemplary compositions in this class include: pentoxifylline; isobutylmethyl xanthine; ciprofloxacin; rolipram; terferol; and the quinolones generally. Each of these IL1/IL6/TNF inhibitors may be administered alone or in combination by a variety of delivery routes and dosage forms, and they may optionally be administered in conjunction with additional active agents including but not limited to metal chelators.