Ray W Wood

US Patent:

7230014, Jun 12, 2007

Filed:

Apr 14, 2000

Appl. No.:

09/549858

Inventors:

James McShane - Wake Forest NC, US
Ray Wood - Raleigh NC, US
Sumio Watanabe - Aichi, JP
Kiyoshi Iwamoto - Kagamihara, JP
Katsumi Onai - Aichi, JP

Assignee:

Eisai Co., Ltd. - Tokyo

International Classification:

A61K 31/44

US Classification:

514338, 514339, 514340, 514556, 514557

Abstract:

The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0. 9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5 C.

US Patent:

7915306, Mar 29, 2011

Filed:

Sep 9, 2003

Appl. No.:

10/657910

Inventors:

Kenichi Chiba - Tsuchiura, JP
Hong Du - North Andover MA, US
Yoshihito Eguchi - Kashiwa, JP
Masanori Fujita - Ushiku, JP
Masaki Goto - Tsuchiura, JP
Fabian Gusovsky - Andover MA, US
Jean-Christophe Harmange - Andover MA, US
Atsushi Inoue - Tsukuba, JP
Megumi Kawada - Ushiku, JP
Takatoshi Kawai - Tsukuba, JP
Yoshiyuki Kawakami - Tsukuba, JP
Akifumi Kimura - Tsukuba, JP
Makoto Kotake - Abiko, JP
Yoshikazu Kuboi - Tsukuba, JP
Tomohiro Matsushima - Ushiku, JP
Yoshiharu Mizui - Tsukuba, JP
Kenzo Muramoto - Tsukuba, JP
Hideki Sakurai - Tsukuba, JP
Yong-Chun Shen - Tewksbury MA, US
Hiroshi Shirota - Belmont CA, US
Mark Spyvee - Hampstead NH, US
Isao Tanaka - Tsukuba, JP
John (Yuan) Wang - Andover MA, US
Ray Wood - Raleigh NC, US
Satoshi Yamamoto - Moriya, JP
Naoki Yoneda - Tsukuba, JP

Assignee:

Eisai Co., Ltd. - Tokyo

International Classification:

A61K 31/335

US Classification:

514449, 514450

Abstract:

The present invention provides compositions comprising compounds having formula (I):.

US Patent:

8097282, Jan 17, 2012

Filed:

Apr 18, 2008

Appl. No.:

12/081670

Inventors:

Ray W. Wood - King of Prussia PA, US
Lan DeCastro - Philadelphia PA, US
H. William Bosch - Bryn Mawr PA, US

Assignee:

Alkermes Pharma Ireland Limited - Athlone, County Westmeath

International Classification:

A61K 9/04
A61K 9/14

US Classification:

424489, 424 94, 424 45, 424400

Abstract:

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

US Patent:

20020177611, Nov 28, 2002

Filed:

May 3, 2002

Appl. No.:

10/137331

Inventors:

James McShane - Wake Forest NC, US
Ray Wood - Raleigh NC, US
Sumio Watanabe - Fuso-cho Aichi, JP
Kiyoshi Iwamoto - Kagamihara-shi, JP
Katsumi Onai - Aichi, JP

International Classification:

A61K031/4439

US Classification:

514/338000

Abstract:

The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5 C.

US Patent:

20040057905, Mar 25, 2004

Filed:

Sep 23, 2003

Appl. No.:

10/667472

Inventors:

Ray Wood - King of Prussia PA, US
Lan DeCastro - King of Prussia PA, US
H. Bosch - Bryn Mawr PA, US

Assignee:

Elan Pharma International Ltd.

International Classification:

A61K049/04
A61L009/04

US Classification:

424/009453, 424/045000

Abstract:

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

US Patent:

20070276008, Nov 29, 2007

Filed:

Feb 6, 2007

Appl. No.:

11/703502

Inventors:

James McShane - Wake Forest NC, US
Ray Wood - Raleigh NC, US
Sumio Watanabe - Fuso-cho, JP
Kiyoshi Iwamoto - Kagamihara-shi, JP
Katsumi Onai - Aichi, JP

Assignee:

Eisai Company Limited - Tokyo

International Classification:

A61K 31/4439
A61P 1/04

US Classification:

514338000

Abstract:

The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5 C.

US Patent:

20080171091, Jul 17, 2008

Filed:

Mar 19, 2008

Appl. No.:

12/051448

Inventors:

Ray W. Wood - Raleigh NC, US
Ian DeCastro - Philadelphia PA, US
H. William Bosch - Bryn Mawr PA, US

International Classification:

A61K 9/50
A61K 31/56

US Classification:

424490, 514180, 977906

Abstract:

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

US Patent:

20090074873, Mar 19, 2009

Filed:

Nov 12, 2008

Appl. No.:

12/292092

Inventors:

Ray W. Wood - Raleigh NC, US
Lan DeCastro - Philadelphia PA, US
H. William Bosch - Bryn Mawr PA, US

International Classification:

A61K 9/14
A61K 31/566
A61P 11/00

US Classification:

424489, 514178

Abstract:

There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.