Raymond D Clark

US Patent:

7919475, Apr 5, 2011

Filed:

Aug 25, 2005

Appl. No.:

11/574232

Inventors:

Wolfgang Dillmann - Solana Beach CA, US
Raymond Clark - San Marcos CA, US

Assignee:

The Regents of The University of California - Oakland CA

International Classification:

A61K 48/00
A01N 63/00
C07H 21/02
C07H 21/04

US Classification:

514 44R, 424 9321, 435325, 536 231, 536 232

Abstract:

The present invention relates to treating or ameliorating heart disease associated with poor myocardial performance, e. g. , diabetic cardiomyopathy and associated disorders, particularly to treating, preventing or ameliorating such disorders through inhibition of O-GlcNAcylation and/or increased activity of O-GlnNAcase. The invention provides vectors for gene transfer of O-GlnNAcase. In one aspect, the invention provides cells, vectors, formulations comprising them and methods of using them, for the gene transfer of the human O-GlnNAcase gene, e. g. , to treat conditions and diseases associated with impaired cardiac contractility, such as that, found associated with diabetic cardiomyopathy. In another aspect, the invention provides non-human transgenic animals and host cells comprising genetically engineered cells having increased activity of O-GlnNAcase.

US Patent:

20030224371, Dec 4, 2003

Filed:

Jun 4, 2002

Appl. No.:

10/160191

Inventors:

Bradley Thomas - Timonium MD, US
Alan Harper - Jamul CA, US
Charles Clemens - Encinitas CA, US
Raymond Clark - Oceanside CA, US
Robert Elms - San Diego CA, US
Lanny Gorton - San Diego CA, US
John Slate - San Diego CA, US
Richard Meyst - Valley Center CA, US

International Classification:

C12Q001/68
C12M001/34

US Classification:

435/006000, 435/287200

Abstract:

An integrated cartridge for automated sample manipulation and, particularly strand displacement amplification, is provided. The cartridge comprises a sealed, two-part device with internal fluid channels and chambers, as well as reagents. The cartridge performs the sequence of fluid transfers, reagent additions and heat transitions, such as those of the strand displacement amplification process, in a single, sealed device.

US Patent:

20060040311, Feb 23, 2006

Filed:

Oct 26, 2005

Appl. No.:

11/258123

Inventors:

Bradley Thomas - Timonium MD, US
Alan Harper - Jamul CA, US
Charles Clemens - Encinitas CA, US
Raymond Clark - Oceanside CA, US
Robert Elms - San Diego CA, US
Lanny Gorton - San Diego CA, US
John Slate - San Diego CA, US
Richard Meyst - Valley Center CA, US

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 1/68
C12M 1/34

US Classification:

435006000, 435287200

Abstract:

An integrated cartridge for automated sample manipulation and, particularly strand displacement amplification, is provided. The cartridge comprises a sealed, two-part device with internal fluid channels and chambers, as well as reagents. The cartridge performs the sequence of fluid transfers, reagent additions and heat transitions, such as those of the strand displacement amplification process, in a single, sealed device.

US Patent:

63324679, Dec 25, 2001

Filed:

Apr 5, 2000

Appl. No.:

9/543126

Inventors:

Lonnie Hutson - San Dimas CA
Leonard Hoffstetter - San Dimas CA
Raymond D. Clark - Oceanside CA

Assignee:

LH Medical Products, Inc. - San Dimas CA

International Classification:

A61F 537

US Classification:

128877

Abstract:

A Feeding tube spike set with integrated Y-port is disclosed. The preferred spike set includes a spike, a drip chamber, a y-port fitting, a stepped connector, and tubing connecting these components to one another in series. The y-port fitting further includes a body, a plug assembly and an undulating retaining member connecting the plug assembly to the body. The plug assembly further includes a plug from which a pair of tabs extend. The body also includes a flushing port formed within it; the preferred flushing port includes a plurality of ridges formed along it's bore to assist in retaining a secure seal between the inserted plug and the body.

US Patent:

D4488482, Oct 2, 2001

Filed:

Apr 5, 2000

Appl. No.:

D/121352

Inventors:

Raymond D. Clark - Oceanside CA
Lonnie Hutson - San Dimas CA
Leonard Hoffstetter - San Dimas CA

Assignee:

LH Medical Products, Inc. - San Dimas CA

International Classification:

2301

US Classification:

D24129