Raymond D Cooper

US Patent:

6410052, Jun 25, 2002

Filed:

Aug 10, 2000

Appl. No.:

09/637840

Inventors:

Raymond Cooper - Mountain View CA
Michael N. Chang - Brisbane CA

Assignee:

Purdue Research Foundation - West Lafayette IN
Pharmanex, Inc. - Brisbane CA

International Classification:

A61K 922

US Classification:

424468, 424729, 514456, 514732, 514738

Abstract:

The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a sustained release formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

US Patent:

6428818, Aug 6, 2002

Filed:

Aug 17, 2000

Appl. No.:

09/640768

Inventors:

Raymond Cooper - Mountain View CA
Howard Sun - San Ramon CA
Qing Ye - Shanghai, CN

Assignee:

Purdue Research Foundation - West Lafayette IN
Pharmanex, Inc. - Brisbane CA

International Classification:

A61K 3578

US Classification:

424729

Abstract:

The invention described herein encompasses methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins with reduced levels of EGCg, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.

US Patent:

20020028258, Mar 7, 2002

Filed:

May 9, 2001

Appl. No.:

09/852132

Inventors:

Lester Mitscher - Lawrence KS, US
Segaran Pillai - Miami FL, US
Raymond Cooper - Mountain View CA, US

Assignee:

Pharmanex, LLC

International Classification:

A61K035/78
A61K031/715

US Classification:

424/737000, 514/054000

Abstract:

The present invention provides immunostimulant compositions and methods for the preparation and use thereof which contain a therapeutically effective amount of an active polysaccharide containing Echinacea extract. In one aspect, the method for making an immunostimulant composition may include the steps of: providing an Echinacea source, extracting an active polysaccharide from the Echinacea source into an aqueous solution, precipitating a water precipitate containing the active polysaccharide from the aqueous solution; and recovering the water precipitate.

US Patent:

20020176898, Nov 28, 2002

Filed:

Apr 3, 2002

Appl. No.:

10/114998

Inventors:

Dorothy Morre - West Lafayette IN, US
D. Morre - West Lafayette IN, US
Raymond Cooper - Mountain View CA, US
Michael Chang - Brisbane CA, US

Assignee:

Purdue Research

International Classification:

A61K035/78
A61K031/7048

US Classification:

424/729000, 514/027000

Abstract:

The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a sustained release formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

US Patent:

61745316, Jan 16, 2001

Filed:

Nov 23, 1998

Appl. No.:

9/198100

Inventors:

De Cheng Zhang - Shanghei, CN
Zhanghun Yu - Shanghei, CN
Raymond Cooper - Los Altos CA
Michael Chang - Thousand Oaks CA

Assignee:

Pharmanex Inc. - Redwood City CA

International Classification:

A61K 3578
A61K 3170
A01N 4304

US Classification:

4241951

Abstract:

The invention relates to a novel process for producing novel extracts of Ginkgo biloba leaves. The invention further relates to a process which produces novel extracts of Ginkgo biloba with an increased amount of one of the major lactones and having an improved biological activity. Further, the disclosed process allows for a controlled method to produce a desired ratio of flavone glycosides to lactones in the end product. The invention also discloses new extracts from Ginkgo biloba, particularly for oral application.