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Raymond Courtney Trievel

age ~78

from Ypsilanti, MI

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Also known as:
  • Raymond C Trievel
  • Raymond G Trievel
  • Jr Raymond Trievel
  • Ray C Trievel
Phone and address:
4653 Nutmeg Dr, Ypsilanti, MI 48197
(734)9618104
Related to:
Connected to:

Raymond Trievel Phones & Addresses

  • 4653 Nutmeg Dr, Ypsilanti, MI 48197 • (734)9618104
  • 4653 Nutmeg Dr #400, Ypsilanti, MI 48197 • (734)6770928
  • Fairfax Station, VA
  • 268 Hay Creek Rd, Birdsboro, PA 19508 • (610)5820475
  • 721 Schoffers Rd, Reading, PA 19606
  • Glen Mills, PA
  • Upper Chichester, PA
  • Upper Darby, PA

Us Patents

  • Method Of Assaying Enzyme-Mediated Oxidative Demethylation

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  • US Patent:
    8173386, May 8, 2012
  • Filed:
    Jan 14, 2009
  • Appl. No.:
    12/353723
  • Inventors:
    Russell Hart - Chelsea MI, US
    Barbara Scheuer - Chelsea MI, US
    Raymond Trievel - Ypsilanti MI, US
  • Assignee:
    Arbor Assays, LLC - Ann Arbor MI
  • International Classification:
    C12Q 1/26
  • US Classification:
    435 25, 436166
  • Abstract:
    Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative demethylation enzyme, a substrate for the oxidative demethylation enzyme and a formaldehyde detection reagent. Detection of fluorescence is indicative of formaldehyde generated by oxidative demethylation of the substrate by the enzyme, the fluorescence resulting from reaction of formaldehyde and the formaldehyde detection reagent.

  • Methyltransferase Assays

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  • US Patent:
    20070224655, Sep 27, 2007
  • Filed:
    Mar 24, 2006
  • Appl. No.:
    11/389393
  • Inventors:
    Raymond Trievel - Ypsilanti MI, US
    Evys Collazo-Santiago - Ann Arbor MI, US
    Jean-Francois Couture - Ann Arbor MI, US
  • Assignee:
    Regents of the University of Michigan - Ann Arbor MI
  • International Classification:
    C12Q 1/48
    C12Q 1/34
  • US Classification:
    435015000, 435018000
  • Abstract:
    The present invention relates to coupled enzyme assays. In particular, the present invention provides a coupled fluorescent assay for detection of S-adenosylmethionine (AdoMet)-dependent methyltransferase activity.

  • Kits For Assaying Enzyme-Mediated Oxidative Demethylation

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  • US Patent:
    20120142038, Jun 7, 2012
  • Filed:
    Feb 14, 2012
  • Appl. No.:
    13/396014
  • Inventors:
    Russell Hart - Chelsea MI, US
    Barbara Scheuer - Chelsea MI, US
    Raymond Trievel - Ypsilanti MI, US
  • International Classification:
    C12Q 1/44
  • US Classification:
    435 19
  • Abstract:
    Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative demethylation enzyme, a substrate for the oxidative demethylation enzyme and a formaldehyde detection reagent. Detection of fluorescence is indicative of formaldehyde generated by oxidative demethylation of the substrate by the enzyme, the fluorescence resulting from reaction of formaldehyde and the formaldehyde detection reagent.

  • Fluorescent Molecular Probes For Use In Assays That Measure Test Compound Competitive Binding With Sam-Utilizing Proteins

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  • US Patent:
    20120295283, Nov 22, 2012
  • Filed:
    May 18, 2012
  • Appl. No.:
    13/475618
  • Inventors:
    Stephen Douglas Barrett - Hartland MI, US
    Daniel Austin Bochar - Ann Arbor MI, US
    Levi Lynn Blazer - Ann Arbor MI, US
    Fred Lawrence Ciske - Dexter MI, US
    Gregory William Endres - Saline MI, US
    Jeffrey Keith Johnson - Ann Arbor MI, US
    Gregory Scott Keyes - Dexter MI, US
    Ranjinder Singh Sidhu - Ann Arbor MI, US
    Raymond C. Trievel - Ypsilanti MI, US
    Margaret Lynn Collins - Canton MI, US
  • Assignee:
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
    CAYMAN CHEMICAL COMPANY, INCORPORATED - Ann Arbor MI
  • International Classification:
    C07D 473/34
    G01N 21/64
  • US Classification:
    435 78, 436501, 544277
  • Abstract:
    Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

  • Methods For Assaying Enzyme-Mediated Oxidative Demethylation

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  • US Patent:
    20140004550, Jan 2, 2014
  • Filed:
    Sep 10, 2013
  • Appl. No.:
    14/022603
  • Inventors:
    Barbara Scheuer - Chelsea MI, US
    Raymond Trievel - Ypsilanti MI, US
  • Assignee:
    ARBOR ASSAYS LLC - Ann Arbor MI
  • International Classification:
    G01N 21/64
  • US Classification:
    435 25
  • Abstract:
    Methods of screening a test agent for activity to modulate an oxidative demethylation enzyme are provided according to embodiments of the present invention which includes preparing a test reaction comprising an oxidative demethylation enzyme, a substrate for the oxidative demethylation enzyme, a test agent and 4-amino-3-penten-2-one under conditions which allow generation of formaldehyde by oxidative demethylation of the substrate by the enzyme in the absence of the test agent; detecting fluorescence in the test reaction, the fluorescence indicative of reaction of formaldehyde and 4-amino-3-penten-2-one in the test reaction; and comparing fluorescence detected in the test reaction with a control, wherein a difference in detected fluorescence is indicative of a change in activity of the oxidative demethylation enzyme in the presence of the test agent.

  • Fluorescent Molecular Probes For Use In Assays That Measure Test Compound Competitive Binding With Sam-Utilizing Proteins

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  • US Patent:
    20150322107, Nov 12, 2015
  • Filed:
    Jul 17, 2015
  • Appl. No.:
    14/801897
  • Inventors:
    - Ann Arbor MI, US
    Levi Lynn Blazer - Ann Arbor MI, US
    Fred Lawrence Ciske - Dexter MI, US
    Gregory William Endres - Saline MI, US
    Jeffrey Keith Johnson - Ann Arbor MI, US
    Gregory Scott Keyes - Dexter MI, US
    Ranjinder Singh Sidhu - Ann Arbor MI, US
    Raymond C. Trievel - Ypsilanti MI, US
    Margaret Lynn Collins - Canton MI, US
  • International Classification:
    C07H 19/16
    G01N 33/58
  • Abstract:
    Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

  • Fluorescent Molecular Probes For Use In Assays That Measure Test Compound Competitive Binding With Sam-Utilizing Proteins

    view source
  • US Patent:
    20150323542, Nov 12, 2015
  • Filed:
    Jul 17, 2015
  • Appl. No.:
    14/801902
  • Inventors:
    - Ann Arbor MI, US
    Levi Lynn Blazer - Ann Arbor MI, US
    Fred Lawrence Ciske - Dexter MI, US
    Gregory William Endres - Saline MI, US
    Jeffrey Keith Johnson - Ann Arbor MI, US
    Gregory Scott Keyes - Dexter MI, US
    Ranjinder Singh Sidhu - Ann Arbor MI, US
    Raymond C. Trievel - Ypsilanti MI, US
    Margaret Lynn Collins - Canton MI, US
  • International Classification:
    G01N 33/58
    G01N 21/64
    C07D 519/00
    C07D 473/34
    C07D 471/04
  • Abstract:
    Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.
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