Remy F Gross

US Patent:

20040028646, Feb 12, 2004

Filed:

Jul 17, 2003

Appl. No.:

10/622094

Inventors:

Remy Gross - Huntsville AL, US
Andreas Kordikowski - Skipton, GB
Raymond Sloan - Bradford, GB

International Classification:

A61K031/765

US Classification:

424/078380

Abstract:

A polyalkylene glycol (PAG)—preferably a polyethylene glycol—or a derivative or conjugate thereof, in particulate form, having a residual solvent content of 200 ppm or less and a volume mean particle diameter of 25 m or less. Also methods for forming particulate products containing PAGs or derivatives or conjugates thereof, in particular by carrying out a GAS process—preferably a Nektar™ SCF process—on a solution or suspension of a target substance but using as the anti-solvent fluid a compressed fluid which at the point of its contact with the solution or suspension is at a temperature of 25 C. or below.

US Patent:

20040167287, Aug 26, 2004

Filed:

Dec 31, 2003

Appl. No.:

10/750996

Inventors:

Antoni Kozlowski - Huntsville AL, US
Remy Gross - Huntsville AL, US
Samuel McManus - Brevard NC, US

International Classification:

C08L039/04

US Classification:

525/205000

Abstract:

The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.

US Patent:

20040204548, Oct 14, 2004

Filed:

Dec 31, 2003

Appl. No.:

10/751274

Inventors:

Antoni Kozlowski - Huntsville AL, US
Remy Gross - Huntsville AL, US
Samuel McManus - Brevard NC, US

International Classification:

C08F008/00

US Classification:

525/326100, 525/286000, 525/374000

Abstract:

The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.

US Patent:

20050014903, Jan 20, 2005

Filed:

Jan 6, 2004

Appl. No.:

10/753047

Inventors:

Antoni Kozlowski - Huntsville AL, US
Remy Gross - Huntsville AL, US
Samuel McManus - Brevard NC, US

International Classification:

C08F022/38

US Classification:

525326900, 525330300, 525333900

Abstract:

The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.

US Patent:

20060009590, Jan 12, 2006

Filed:

Mar 25, 2005

Appl. No.:

11/091024

Inventors:

Antoni Kozlowski - Huntsville AL, US
Remy Gross - Petaluma CA, US
Samuel McManus - Brevard NC, US

International Classification:

C08C 19/22

US Classification:

525374000, 525056000

Abstract:

The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.

US Patent:

20080146771, Jun 19, 2008

Filed:

Sep 27, 2007

Appl. No.:

11/904990

Inventors:

Antoni Kozlowski - Huntsville AL, US
Remy F. Gross - Huntsville AL, US
Samuel P. McManus - Brevard NC, US

International Classification:

C08G 73/10

US Classification:

528322

Abstract:

The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.

US Patent:

20090012241, Jan 8, 2009

Filed:

Aug 26, 2008

Appl. No.:

12/229650

Inventors:

Antoni Kozlowski - Huntsville AL, US
Remy F. Gross III - Petaluma CA, US
Samuel P. McManus - Huntsville AL, US

Assignee:

Nektar Therapeutics AL, Corporation - Huntsville AL

International Classification:

C08G 73/14

US Classification:

525418, 528322

Abstract:

The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.

US Patent:

20130079555, Mar 28, 2013

Filed:

Nov 19, 2012

Appl. No.:

13/681357

Inventors:

Nektar Therapeutics - San Francisco CA, US
Remy F. Gross - Petaluma CA, US
Samuel P. McManus - Guntersville AL, US

Assignee:

Nektar Therapeutics - San Francisco CA

International Classification:

C07C 319/06

US Classification:

564154, 564203

Abstract:

The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.