Ricardo C Fernandez

US Patent:

20090162839, Jun 25, 2009

Filed:

Aug 31, 2005

Appl. No.:

11/574449

Inventors:

Ruth L. Katz - Houston TX, US
Jun Gu - Houston TX, US
Abha Khanna - Houston TX, US
Ricardo Fernandez - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention concerns a quantitative in situ assessment of mean telomere length, particularly in relation to nuclear area, for the diagnosis and/or prognosis of cancer. In particular aspects, the methods and compositions regard diagnosis and/or prognosis of bladder cancer, urothelial cancer, lung cancer, and lymphoma.

US Patent:

20100317002, Dec 16, 2010

Filed:

Oct 6, 2008

Appl. No.:

12/682594

Inventors:

Michal Daniely - Ganei Tikva, IL
Lea Madi - Rishon-LeZion, IL
Tal Kaplan - Gan-Yavne, IL
Boaz Pal - Tel-Aviv, IL
Yuval Harari - D.N. Emek Soreq, IL
Tanweer M. Zaidi - Houston TX, US
Ricardo L. Fernandez - Houston TX, US
Jinping Zhang - Houston TX, US
Ruth Katz - Houston TX, US

Assignee:

Bioview Ltd. - Nes Ziona

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Provided is a method of identifying a genetically abnormal cell in a sputum sample, the method comprising: (a) staining a sputum sample using a morphological stain so as to identify a lower airway tract cell or lung cell in the sputum sample; and (b) staining the sputum sample using fluorescent in situ hybridization (FISH) so as to identify in the lower airway tract cell or lung cell a genetic abnormality in at least one of human chromosome 3p22.1 and 10q22-23, thereby identifying the genetically abnormal cell in the sputum sample. Also provided are methods and kits of diagnosing lung cancer by detecting a presence of genetically abnormal cells above a predetermined threshold in a sputum sample.

US Patent:

20110189670, Aug 4, 2011

Filed:

Jul 7, 2009

Appl. No.:

13/002944

Inventors:

Ruth L Katz - Houston TX, US
Abha Khanna - Sugar Land TX, US
Tanweer M. Zaidi - Missouri City TX, US
Weigong He - Sugar Land TX, US
Ricardo L. Fernandez - Houston TX, US
Ivan Gorlov - Houston TX, US

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The present invention comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. The method comprises contacting a sample with a CD45 binding agent; selecting the cells based on positive or negative CD45 staining; contacting the selected cells with a labeled nucleic acid probe, and detecting hybridized cells by fluorescence in situ hybridization; and analyzing a signal produced by the labels on the hybridized cells to detect the CTCs. In other embodiments, the method provides for directed to a method of determining the level of CTCs in a sample having blood cells from a patient by contacting a sample having blood cells from a patient, wherein the sample has not been pre-sorted into CD45-positive and CD45-negative cells.

US Patent:

20230065915, Mar 2, 2023

Filed:

Aug 30, 2021

Appl. No.:

17/461120

Inventors:

- Palo Alto CA, US
Stefano Andrea Romano - Houston TX, US
Ricardo Antonio Fernandez - Katy TX, US
Joseph Michael Price - Houston TX, US

International Classification:

G06K 9/00
G06K 9/62
G06K 9/20
G06F 40/30

Abstract:

The accuracy of existing machine learning models, software technologies, and computers are improved by using one or more machine learning models to map data inside structural elements, such as rows or columns, as found within a document to data objects of other documents, where the data objects are at least partially indicative of candidate categories that the data can belong to.