Rich Bakke Meyer

US Patent:

8436025, May 7, 2013

Filed:

Sep 17, 2009

Appl. No.:

12/561750

Inventors:

Janet Ajioka - Seattle WA, US
Heidi S. Hummel - Seattle WA, US
Rich B. Meyer - San Mateo CA, US
John Swindle - Seattle WA, US

Assignee:

CompleGen Partners, Inc. - Seattle WA

International Classification:

A61K 31/136
A61K 31/4412
A61P 29/00
A61P 37/06
A61P 3/10

US Classification:

514349, 514646

Abstract:

The present invention provides a method of selectively inhibiting PKCθ in the presence of PKCδ, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.

US Patent:

8551408, Oct 8, 2013

Filed:

Jan 24, 2007

Appl. No.:

11/626842

Inventors:

Matthew P. Beaudet - Eugene OR, US
David C. Hagen - Eugene OR, US
Jill Hendrickson - Eugene OR, US
Rich B. Meyer - San Mateo CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 21/64

US Classification:

422 8208, 422 8205, 422 67, 436172

Abstract:

The present invention relates to devices and methods for measuring the quantity of multiple analytes in a sample. The device is designed such that each of the analyte sensing elements is configured to measure the quantity of a predetermined analyte and where the machine executable instructions are configured to select the proper analyte sensing element corresponding to the analyte to be measured.

US Patent:

8623282, Jan 7, 2014

Filed:

Sep 12, 2012

Appl. No.:

13/611713

Inventors:

Matthew P. Beaudet - Eugene OR, US
David C. Hagen - Eugene OR, US
Jill Hendrickson - Eugene OR, US
Rich B. Meyer - San Mateo CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 21/64

US Classification:

422 8202, 422 8205, 422 8208, 422 67, 436172

Abstract:

The present invention relates to devices and methods for measuring the quantity of multiple analytes in a sample. The device is designed such that each of the analyte sensing elements is configured to measure the quantity of a predetermined analyte and where the machine executable instructions are configured to select the proper analyte sensing element corresponding to the analyte to be measured.

US Patent:

20040058322, Mar 25, 2004

Filed:

Apr 22, 2002

Appl. No.:

10/127936

Inventors:

Joel Hedgpeth - San Francisco CA, US
Irina Afonina - Mill Creek WA, US
Igor Kutyavin - Bothell WA, US
Eugeny Lukhtanov - Bothell WA, US
Evgeniy Belousov - Mill Creek WA, US
Rich Meyer - Bothell WA, US

Assignee:

Epoch Pharmaceuticals, Inc. - Bothell WA

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPIgroup resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

US Patent:

20050064463, Mar 24, 2005

Filed:

Jun 16, 2004

Appl. No.:

10/870578

Inventors:

Joel Hedgpeth - San Francisco CA, US
Irina Afonina - Mill Creek WA, US
Igor Kutyavin - Bothell WA, US
Eugeny Lukhtanov - Bothell WA, US
Evgeniy Belousov - Mill Creek WA, US
Rich Meyer - Bothell WA, US

International Classification:

C12Q001/68
C07H021/04
C12P019/34

US Classification:

435006000, 435091200, 536024300

Abstract:

Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPIgroup resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

US Patent:

20140011191, Jan 9, 2014

Filed:

Sep 4, 2013

Appl. No.:

14/017965

Inventors:

Jill Hendrickson - Eugene OR, US
David Hagen - Eugene OR, US
Rich Meyer - San Mateo CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

G01N 21/64

US Classification:

435 5, 435 39, 436 86, 436 94, 435 724, 435 21, 435 18, 435 25, 435 24, 4352872, 4352887, 422 8205

Abstract:

The present invention relates to devices and methods for measuring the quantity of multiple analytes in a sample. The device is designed such that each of the analyte sensing elements is configured to measure the quantity of a predetermined analyte and where the machine executable instructions are configured to select the proper analyte sensing element corresponding to the analyte to be measured.

US Patent:

63128942, Nov 6, 2001

Filed:

Apr 3, 1998

Appl. No.:

9/054832

Inventors:

Joel Hedgpeth - San Francisco CA
Irina A. Afonina - Mill Creek WA
Igor V. Kutyavin - Bothell WA
Eugeny A. Lukhtanov - Bothell WA
Evgeniy S. Belousov - Mill Creek WA
Rich B. Meyer - Bothell WA

Assignee:

Epoch Pharmaceuticals, Inc. - Bothell WA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI. sub. 3), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI. sub. 3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

US Patent:

20200292456, Sep 17, 2020

Filed:

Jan 7, 2020

Appl. No.:

16/735856

Inventors:

- Carlsbad CA, US
Jill HENDRICKSON - Eugene OR, US
David HAGEN - Eugene OR, US
Rich MEYER - San Mateo CA, US

International Classification:

G01N 21/64
B01L 7/00

Abstract:

Devices and methods for measuring the quantity of multiple analytes in a sample can include a device designed such that each of the analyte sensing elements is configured to measure the quantity of a predetermined analyte and machine executable instructions configured to select the proper analyte sensing element corresponding to the analyte to be measured.