Richard L Bringham

US Patent:

7572622, Aug 11, 2009

Filed:

Aug 14, 2003

Appl. No.:

10/640867

Inventors:

Waleed H. Hassanein - North Andover MA, US
Richard L. Bringham - North Andover MA, US

Assignee:

TransMedic, Inc. - Andover MA

International Classification:

A01N 1/02

US Classification:

4352841, 435 12

Abstract:

A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels.

US Patent:

7651835, Jan 26, 2010

Filed:

Oct 7, 2005

Appl. No.:

11/246905

Inventors:

Waleed Hassanein - Andover MA, US
Richard Bringham - North Andover MA, US
Giovanni Cecere - Sudbury MA, US
Robert Fishman - Somerville MA, US
Larry Goff - Andover MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Burt Ochs - Andover MA, US
Scott Newell - Ipswich MA, US
Ronald Taylor - Chester NH, US
Hossam Algamil - Scranton PA, US
Thomas Bishop - Wenham MA, US
Robert Havner - Lynnfield MA, US
Dmitri Menn - Marblehead MA, US

Assignee:

TransMedics, Inc. - Andover MA

International Classification:

A01N 1/02

US Classification:

435 12

Abstract:

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

US Patent:

8420380, Apr 16, 2013

Filed:

Apr 8, 2008

Appl. No.:

12/099717

Inventors:

Robert Fishman - Boston MA, US
Robert Havener - Lynnfield MA, US
Ihab Abdel Fattah - Andover MA, US
Anas Abdelazim - North Andover MA, US
Scott Newell - Ipswich MA, US
Tom Bishop - Wenham MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Ron Taylor - Chester NH, US
Doug Harriott - Melrose MA, US
Matthew De Remer - Allston MA, US
Paul Murray - Groton MA, US
John Sullivan - Groton MA, US
Mark Anderson - Danvers MA, US
Richard Bringham - North Andover MA, US
Michael Van Driel - Mirandola, IT
Waleed Hassanein - North Andover MA, US

Assignee:

TransMedics, Inc. - Andover MA

International Classification:

A01N 1/02

US Classification:

4352841, 435 12

Abstract:

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

US Patent:

8465970, Jun 18, 2013

Filed:

Oct 7, 2005

Appl. No.:

11/246902

Inventors:

Waleed Hassanein - Andover MA, US
Richard Bringham - North Andover MA, US
Giovanni Cecere - Sudbury MA, US
Robert Fishman - Somerville MA, US
Larry Goff - Andover MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Scott Newell - Ipswich MA, US
Burt Ochs - Andover MA, US
Dennis Sousa - Stoughton MA, US
Ronald Taylor - Chester NH, US
Jonathan Rourke - Belmont MA, US
Hossam Algamil - Scranton PA, US
David Carpenter - Jaffrey NH, US
Robert Havner - Lynnfield MA, US
Dmitri Menn - Marblehead MA, US

Assignee:

TransMedics, Inc. - Andover MA

International Classification:

C12M 1/12

US Classification:

4352972, 435 12

Abstract:

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

US Patent:

8585380, Nov 19, 2013

Filed:

Oct 7, 2005

Appl. No.:

11/245958

Inventors:

Waleed Hassanein - Andover MA, US
Richard Bringham - North Andover MA, US
Robert Fishman - Somerville MA, US
Larry Goff - Andover MA, US
Stanley Kyi - Andover MA, US
Jonathan Rourke - Belmont MA, US
Dmitri Menn - Marblehead MA, US
David Carpenter - Jaffrey NH, US
Robert Havner - Lynnfield MA, US

Assignee:

Transmedics, Inc. - Andover MA

International Classification:

F04B 7/00
A61M 1/00

US Classification:

417510, 417437, 417475, 417443, 417472, 417474, 417460, 4352841, 435 11, 435 12, 4352891

Abstract:

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

US Patent:

20060148062, Jul 6, 2006

Filed:

Oct 7, 2005

Appl. No.:

11/245957

Inventors:

Waleed Hassanein - Andover MA, US
Richard Bringham - North Andover MA, US
Giovanni Cecere - Sudbury MA, US
Tamer Khayal - North Andover MA, US
Ronald Taylor - Chester NH, US
Hoss Algamil - Scranton PA, US

Assignee:

TransMedics, Inc. - Andover MA

International Classification:

A01N 1/02

US Classification:

435284100

Abstract:

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

US Patent:

20060154357, Jul 13, 2006

Filed:

Oct 7, 2005

Appl. No.:

11/246013

Inventors:

Waleed Hassanein - Andover MA, US
Richard Bringham - North Andover MA, US
Giovanni Cecere - Sudbury MA, US
Robert Fishman - Somerville MA, US
Larry Goff - Andover MA, US
Tamer Khayal - North Andover MA, US
Stanley Kyi - Andover MA, US
Scott Newell - Ipswich MA, US
Burt Ochs - Andover MA, US
Dennis Sousa - Stoughton MA, US
Ronald Taylor - Chester NH, US
Jonathan Rourke - Belmont MA, US
Hossam Algamil - Scranton PA, US
David Carpenter - Jaffrey NH, US
Robert Havner - Lynnfield MA, US
Dmitri Menn - Marblehead MA, US

Assignee:

TRANSMEDICS, INC. - Woburn MA

International Classification:

A01N 1/02

US Classification:

435284100, 435286500

Abstract:

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

US Patent:

20080234768, Sep 25, 2008

Filed:

Jul 6, 2007

Appl. No.:

11/822495

Inventors:

Waleed Hassanein - North Andover MA, US
Richard Bringham - North Andover MA, US
Robert Havener - Lynnfield MA, US
Vincent Lambert - Salisbury MA, US
Burt Ochs - Andover MA, US

Assignee:

TransMedics, Inc - Andover MA

International Classification:

A61N 1/04

US Classification:

607 4

Abstract:

Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.