Richard C Burt

US Patent:

20050221482, Oct 6, 2005

Filed:

Mar 31, 2005

Appl. No.:

11/094977

Inventors:

Richard Burt - Evanston IL, US
Larissa Verda - Evanston IL, US
Charles Link - Ames IA, US

International Classification:

C12N005/08
C12N005/06

US Classification:

435372000, 435354000

Abstract:

The present invention provides an isolated population of adult hematopoietic stem cells (HSC) derived from embryonic stem cells (ESC) induced to differentiate in vitro by culturing ESCs in a medium with stem cell factor, interleukin (IL)-3, and IL-6. HSC of immunophenotype c-kit or c-kit+/CD45 from this population are isolated and injected either intra bone marrow or intravenously into myeloablated recipient individuals. This method allows for the establishment of banks of allogeneic ESC-derived adult stem cells for treatments of autoimmune diseases, immune deficiencies and induction of immunotolerance during organ transplantation. These allogeneic ESC-derived adult hematopoietic stem cells (HSC) may be used in reconstituting bone marrow, without the development of teratomas or graft versus host disease, despite crossing histocompatibility barriers. Additionally, allogeneic ESC-derived HSC can be used to prevent the development of autoimmune diseases or organ rejection during transplantation.

US Patent:

20090214491, Aug 27, 2009

Filed:

Jan 15, 2009

Appl. No.:

12/354522

Inventors:

Richard Burt - Chicago IL, US

International Classification:

A61K 35/12
C12N 5/02
C12N 13/00

US Classification:

424 937, 435325, 4351731

Abstract:

The present invention is directed to the use of mitotically and/or lethally inactivated stem cells for the repair of damaged organs and/or tissues. Stem cells are mitotically and/or lethally inactivated and transplanted into damaged tissue. Any form of ex vivo inactivation of stem cells may be used such that the stem cells cannot undergo mitosis or cell division before in vivo application. Mitotically and/or lethally inactivated stem may be used to ameliorate numerous disease, injury, traumatic, ischemic, aging, and/or degenerative conditions in different types of organs and/or tissues.

US Patent:

20130243739, Sep 19, 2013

Filed:

Mar 13, 2013

Appl. No.:

13/800281

Inventors:

Richard Burt - Chicago IL, US

International Classification:

A61K 35/12
A61Q 19/08
A61K 8/98

US Classification:

424 937, 435366

Abstract:

Compositions and methods are provided herein for regenerating and repairing damaged or aged tissue or organs using nonviable lethally irradiated or lyophilized pluripotent stem cells. In one aspect, the compositions and methods described herein provide anti-aging benefits to the skin by increasing the hydration reducing fine lines, wrinkles, and pores of the skin. Compositions and methods are also provided for promoting wound healing using lyophilized pluripotent stem cell powder. A method is provided for inducing cardiac muscle regeneration in a primate comprising delivering nonviable lethally irradiated pluripotent stem cells to damaged or aged areas of the heart. The compositions and methods include nonviable lethally irradiated or lyophilized pluripotent stem cells. In one aspect, the compositions and methods utilize nonviable pluripotent stem cells in the form of a powder, such as lyophilized stem cells.

US Patent:

20180296610, Oct 18, 2018

Filed:

Jun 19, 2018

Appl. No.:

16/012197

Inventors:

Richard K. Burt - Chicago IL, US

International Classification:

A61K 35/545
A61K 9/08
A61K 9/00
A61K 47/26
A61K 9/19

Abstract:

The disclosure is directed to the use of nonviable pluripotent stem cells to improve age-related declines in tissue and organ function. In one aspect, nonviable pluripotent stem cells are used to improve cognition in a subject in need thereof. In another aspect, nonviable pluripotent stem cells are used to improve age-related cardiac dysfunction in a subject in need thereof. Administration of nonviable pluripotent stem cells provides a transient and safe form of heterochronic cellular transbiosis.

US Patent:

20170106024, Apr 20, 2017

Filed:

Sep 26, 2016

Appl. No.:

15/276120

Inventors:

Richard K. Burt - Chicago IL, US

International Classification:

A61K 35/545
A61K 9/08
A61K 9/19

Abstract:

The disclosure is directed to the use of nonviable pluripotent stem cells to improve age-related declines in tissue and organ function. In one aspect, nonviable pluripotent stem cells are used to improve cognition in a subject in need thereof. In another aspect, nonviable pluripotent stem cells are used to improve age-related cardiac dysfunction in a subject in need thereof. Administration of nonviable pluripotent stem cells provides a transient and safe form of heterochronic cellular transbiosis.

US Patent:

20160310544, Oct 27, 2016

Filed:

Jul 1, 2016

Appl. No.:

15/200303

Inventors:

Richard K. Burt - Chicago IL, US

International Classification:

A61K 35/545
C12N 5/0735

Abstract:

Compositions and methods are provided herein for regenerating and repairing damaged or aged tissue or organs using nonviable lethally irradiated or lyophilized pluripotent stem cells. In one aspect, the compositions and methods described herein provide anti-aging benefits to the skin by increasing the hydration reducing fine lines, wrinkles, and pores of the skin. Compositions and methods are also provided for promoting wound healing using lyophilized pluripotent stem cell powder. A method is provided for inducing cardiac muscle regeneration in a primate comprising delivering nonviable lethally irradiated pluripotent stem cells to damaged or aged areas of the heart. The compositions and methods include nonviable lethally irradiated or lyophilized pluripotent stem cells. In one aspect, the compositions and methods utilize nonviable pluripotent stem cells in the form of a powder, such as lyophilized stem cells.

US Patent:

20160022744, Jan 28, 2016

Filed:

Oct 5, 2015

Appl. No.:

14/875363

Inventors:

Richard Burt - Chicago IL, US

International Classification:

A61K 35/545
C12N 5/0735

Abstract:

The present invention is directed to the use of mitotically and/or lethally inactivated stem cells for the repair of damaged organs and/or tissues. Stem cells are mitotically and/or lethally inactivated and transplanted into damaged tissue. Any form of ex vivo inactivation of stem cells may be used such that the stem cells cannot undergo mitosis or cell division before in vivo application. Mitotically and/or lethally inactivated stem may be used to ameliorate numerous disease, injury, traumatic, ischemic, aging, and/or degenerative conditions in different types of organs and/or tissues.

US Patent:

20150328265, Nov 19, 2015

Filed:

Apr 27, 2015

Appl. No.:

14/697281

Inventors:

Richard Burt - Chicago IL, US

International Classification:

A61K 35/545

Abstract:

The present invention is directed to the use of mitotically and/or lethally inactivated stem cells for the repair of damaged organs and/or tissues. Stem cells are mitotically and/or lethally inactivated and transplanted into damaged tissue. Any form of ex vivo inactivation of stem cells may be used such that the stem cells cannot undergo mitosis or cell division before in vivo application. Mitotically and/or lethally inactivated stem may be used to ameliorate numerous disease, injury, traumatic, ischemic, aging, and/or degenerative conditions in different types of organs and/or tissues.