Richard J Gabriel

US Patent:

60204958, Feb 1, 2000

Filed:

Dec 8, 1997

Appl. No.:

8/986834

Inventors:

Xiaoyong Sun - Acton MA
Yesh P. Sachdeva - Concord MA
Donna Kaye Wilson - Billerica MA
Richard L. Gabriel - Swampscott MA
Siya Ram - Winchester MA

Assignee:

Pharm-Eco Laboratories, Inc. - Lexington MA

International Classification:

C07D27720

US Classification:

548202

Abstract:

The present invention relates to a method for the stereospecific synthesis of an enantiomer of a chiral amine, wherein the chiral amine has the formula R. sup. 1 CH(NH. sub. 2)R. sup. 2. R. sup. 1 and R. sup. 2 are each independently selected from the group consisting of alkyl, aryl and heterocyclic and radicals. This method is particularly useful for stereospecifically synthesizing S-dolaphenine. The method involves contacting a chiral enantiomer of norephedrine with borane, within an aprotic solvent to form a complex for stereospecifically reducing oximes. The complex is then contacted with an oxime, thereby stereospecifically reducing said oxime to form an enantiomer of a chiral amine.

US Patent:

54751381, Dec 12, 1995

Filed:

Jul 7, 1994

Appl. No.:

8/271619

Inventors:

Biman Pal - Waltham MA
Siya Ram - Winchester MA
Bing Cai - Woburn MA
Yesh P. Sachdeva - Concord MA
Jaechul Shim - Cambridge MA
Salah A. Zahr - Acton MA
Emile Al-Farhan - W. Roxbury MA
Richard Gabriel - Swampscott MA

Assignee:

Pharm-Eco Laboratories Incorporated - Lexington MA

International Classification:

C07C21528
C07C21300
C07C22934
C07C22702
C07D20729

US Classification:

564342

Abstract:

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

US Patent:

54038510, Apr 4, 1995

Filed:

Apr 5, 1994

Appl. No.:

8/223352

Inventors:

Kay J. D'Orlando - Wayland MA
Kenneth W. Locke - Littleton MA
Emile M. Bellott - Beverly MA
Richard L. Gabriel - Swampscott MA
Michael D. Nohrden - Stow MA
Yesh P. Sachdeva - Concord MA
Salah A. Zahr - Acton MA
Emile Al-Farhan - West Roxbury MA
Subramaniam Krishnananthan - Waltham MA

Assignee:

Interneuron Pharmaceuticals, Inc. - Lexington MA

International Classification:

A61K 3142
A61K 3141
C07D27110
C07D20908

US Classification:

514364

Abstract:

This invention relates to novel substituted tryptamine and phenalkylamine and related compounds, pharmaceutical compositions thereof and methods of using said compounds and compositions for a number of pharmaceutical indications including (but not limited to): 1. central nervous system and psychiatric disorders (e. g. , sleep disorders, epilepsy and other convulsive disorders, anxiety, psychiatric diseases, neurodegenerative diseases, fever); 2. chronobiological-based disorders (e. g. , jet lag, delayed sleep syndrome, shift-work, seasonal affective disorder); 3. endocrine indications (e. g. , contraception and infertility, precocious puberty, premenstrual syndrome, hyperprolactinemia, growth hormone deficiency); 4. cancer and other proliferative diseases; 5. immune system disorders and conditions associated with senescence; 6.

US Patent:

55999948, Feb 4, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/487294

Inventors:

Biman Pal - Waltham MA
Siya Ram - Winchester MA
Yesh P. Sachdeva - Concord MA
Jaechul Shim - Cambridge MA
Salah A. Zahr - Acton MA
Emile Al-Farhan - Dedham MA
Richard L. Gabriel - Swampscott MA

Assignee:

Pharm-Eco Laboratories, Inc. - Lexington MA

International Classification:

C07C21528
C07C21300
C07C22934
C07C22702

US Classification:

564355

Abstract:

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

US Patent:

60639636, May 16, 2000

Filed:

Aug 4, 1997

Appl. No.:

8/765283

Inventors:

Biman Pal - Waltham MA
Siya Ram - Winchester MA
Bing Cai - Westfield NJ
Yesh P. Sachdeva - Concord MA
Jaechul Shim - Lexington MA
Salah A. Zahr - Acton MA
Emile Al-Farhan - Dedham MA
Richard Gabriel - Swampscott MA

Assignee:

Pharm-Eco Laboratories, Inc. - Lexington MA

International Classification:

C07C20936

US Classification:

564336

Abstract:

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

US Patent:

56189664, Apr 8, 1997

Filed:

May 16, 1995

Appl. No.:

8/442117

Inventors:

Biman Pal - Waltham MA
Siya Ram - Winchester MA
Bing Cai - Woburn MA
Yesh P. Sachdeva - Concord MA
Jaechul Shim - Cambridge MA
Salah A. Zahr - Acton MA
Emile Al-Farhan - W. Roxbury MA
Richard Gabriel - Swampscott MA

Assignee:

Pharm-Eco Laboratories, Incorporated - Lexington MA

International Classification:

C07C22934
C07C21528
C07C21300
C07C22702
C07D40312

US Classification:

560 16

Abstract:

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

US Patent:

56314051, May 20, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/472496

Inventors:

Biman Pal - Waltham MA
Siya Ram - Winchester MA
Bing Cai - Iselin NJ
Yesh P. Sachdeva - Concord MA
Jaechul Shim - Cambridge MA
Salah A. Zahr - Acton MA
Emile Al-Farhan - Dedham MA
Richard L. Gabriel - Swampscott MA

Assignee:

Pharm-Eco Laboratories, Incorporated - Lexington MA

International Classification:

C07C21528
C07C21300
C07C22934
C07C22702

US Classification:

564342

Abstract:

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

US Patent:

56309147, May 20, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/478945

Inventors:

Yesh P. Sachdeva - Burlington MA
Richard L. Gabriel - Swampscott MA

Assignee:

Pharm-Eco Laboratories, Inc. - Lexington MA

International Classification:

B01D 114
B01D 122
B01D 328

US Classification:

203 49

Abstract:

A method for decontaminating a liquid of a contaminant having a vapor pressure which is higher than the vapor pressure of the liquid. A contaminated liquid is directed through an inclined conduit. A gas is directed into the inclined conduit, whereby the gas contacts the liquid and transports the contaminant, which has volatilized in the inclined conduit, out of the inclined conduit, thereby decontaminating the liquid. The liquid is discharged from the inclined conduit.