Richard A Gambale

US Patent:

6331185, Dec 18, 2001

Filed:

Sep 30, 1998

Appl. No.:

9/164163

Inventors:

Richard A. Gambale - Tyngsboro MA
Stephen J. Forcucci - Arlington MA
Michael F. Weiser - Groton MA
Richard T. Choh - Lowell MA
Sean Forde - Watertown MA

Assignee:

C.R. Bard, Inc. - Murray Hill NJ

International Classification:

A61F 206

US Classification:

623 11

Abstract:

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

US Patent:

6447522, Sep 10, 2002

Filed:

Jun 18, 2001

Appl. No.:

09/883658

Inventors:

Richard A. Gambale - Tyngsboro MA
John E. Ahern - Melrose MA
Michael Parascandola - Londonderry NH

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61F 1100

US Classification:

606108, 606194, 623 111, 623 122

Abstract:

The present invention provides an implant delivery system for placing interior defining implants in the human body. The devices comprise elongate shafts and a mechanism at the distal end of the shaft for engaging and retaining the implant in place on the shaft during delivery through the vessels and insertion of the distal end of the shaft into tissue. Some embodiments of the devices are configured to have a plurality of implants and configured to deliver the implants sequentially to a plurality of locations. One embodiment employs a flexible outer tube at its distal end that compresses and crinkles to a larger diameter upon being compressed lengthwise to engage the inside surface of the implant. Another embodiment utilizes a tubular delivery shaft having a circular cross section with segments of oval shaped cross sections which serve to engage the inside of implant located on the shaft. A cam slidable within the shaft engages the oval areas, deforming them to a circular shape which permits the implants to be released.

US Patent:

6458092, Oct 1, 2002

Filed:

Sep 30, 1998

Appl. No.:

09/164173

Inventors:

Richard A. Gambale - Tyngsboro MA
Stephen J. Forcucci - Arlington MA
Michael F. Weiser - Groton MA
Richard T. Choh - Lowell MA
Sean Forde - Watertown MA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61B 1720

US Classification:

604 22, 604 9301

Abstract:

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.

US Patent:

6461370, Oct 8, 2002

Filed:

Dec 6, 1999

Appl. No.:

09/457203

Inventors:

William Gray - Corrales NM
Richard A. Gambale - Tyngsboro MA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61F 201

US Classification:

606200

Abstract:

A vascular filter guide wire is disclosed for directing precision placement of a cur proximate a blood vessel lesion and filtering particulate matter dislodged by treatment of the vessel. The guide wire includes an actuating mechanism, an elongated flexible core wile having a proximal end mounted to the actuating mechanism and a distal end for insertion through a vasculature to a position downstream of the restriction. A tubular flexible shaft is slidably disposed telescopically along the core wire and includes a proximal portion affixed to the actuating mechanism in movable relation to the core wire. The guide wire includes a collapsible filter at its proximal end to the distal portion of the shaft and, at its distal end, to the core wire. The filter deploys radially in response to axial moment of the core wire relative to the shaft so that it can trap particulate matter arising from treatment of the lesion.

US Patent:

6517527, Feb 11, 2003

Filed:

Jun 25, 2001

Appl. No.:

09/888750

Inventors:

Richard A. Gambale - Tyngsboro MA
Stephen J. Forcucci - Arlington MA
Richard T. Choh - Lowell MA
Robert Cafferata - Belmont MA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61M 3100

US Classification:

604508

Abstract:

The present invention provides a transthoracic drug delivery device that utilizes pressure to determine the precise location of the distal tip of the delivery tube of the device to insure that therapeutic substances are ejected into the myocardium and not dissipated in unintended tissue locations. In one embodiment the drug delivery device comprises a pressure sensing tube mounted in parallel to a drug delivery tube wherein the tubes are staggered so that the pressure tube extends beyond the delivery tube. When the myocardium is penetrated by the tubes, advancement into the heart and penetration into the left ventricle by the pressures sensing tube results in a pressure increase that indicates to the physician that the drug delivery tube, by its placement relative to the pressure sensing tube is still in the myocardium and, thus, prepared to deliver the drug. In another embodiment, a steerable syringe is provided so that multiple sites in the myocardium can be treated with a therapeutic substance with only one penetration into the heart. Once the delivery tube of the syringe penetrates the left ventricle, its distal tip can be deflected back toward the endocardial surface and the tube withdrawn proximally to cause penetration of the tip into the myocardium.

US Patent:

6629987, Oct 7, 2003

Filed:

Jul 30, 1999

Appl. No.:

09/364520

Inventors:

Richard A. Gambale - Tyngsboro MA
Stephen J. Forcucci - Medford MA
Chirag B. Shah - Nashua NH
Michael F. Weiser - Groton MA
Sean Forde - Watertown MA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61M 2900

US Classification:

606198, 606191, 604106, 604107, 604108, 604109, 604175

Abstract:

The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward. In another embodiment radially projecting fingers are joined to the distal end of the catheter, which remain retracted during navigation of the catheter to the treatment site then are extended outward to penetrate the tissue and secure the catheter at the treatment site upon being actuated from the proximal end of the catheter by a physician.

US Patent:

6692520, Feb 17, 2004

Filed:

Dec 15, 1998

Appl. No.:

09/211332

Inventors:

Richard A. Gambale - Tyngsboro MA
Mike Weiser - Groton MA
Stephen Forcucci - Arlington MA
Chirag B. Shah - Nashua NH

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61F 206

US Classification:

623 11, 623 1111, 623 2372

Abstract:

The invention includes systems and methods for stimulating intramuscular angiogenesis by placing a biocompatible device within the tissue of a muscle. The biocompatible device is dimensionally adapted for placement within the tissue of a muscle. Placement of the biocompatible device within the muscle can take place according to the method of the invention by using techniques familiar to those of ordinary skill in the art. Illustrative techniques for placement of the device within the myocardium comprise one practice of the method of the invention.

US Patent:

6709425, Mar 23, 2004

Filed:

Jan 31, 2001

Appl. No.:

09/774319

Inventors:

Richard A. Gambale - Tyngsboro MA
Stephen J. Forcucci - Medford MA
Michael F. Weiser - Groton MA
Richard T. Choh - Waltham MA
Sean Forde - Watertown MA

Assignee:

C. R. Bard, Inc. - Murray Hill NJ

International Classification:

A61M 3100

US Classification:

604500, 623 142

Abstract:

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.