Richard C Holz

US Patent:

20050026873, Feb 3, 2005

Filed:

Feb 25, 2004

Appl. No.:

10/786240

Inventors:

Richard Holz - Providence UT, US
Alicja Copik - Logan UT, US
Krzysztof Swierczek - Logan UT, US
Sabina Swierczek - Logan UT, US

International Classification:

A61K031/675
C07F009/28
A61K031/66
C07D285/12

US Classification:

514114000, 514363000, 514364000, 514365000, 514374000, 514383000, 514406000, 548136000, 548143000, 548200000, 548217000, 548253000, 548335500, 548364100, 562011000

Abstract:

Novel compounds act as molecular inhibitors to target new enzymatic targets on bacteria and provide a new class of bactericidal compounds. The compounds provide for selective inhibition of Type I methionyl aminopeptidases (MetAPs) in bacteria. Because humans and other animals have both type-I and type-II MetAPs, which are functionally equivalent, the compounds are bactericidal but do not completely inhibit MetAP activity in humans and other animals. The compounds also have anti-microbial activity in microbes other than bacteria provided the targeted microbes have predominately type-I MetAP.