Richard Harold Ingraham - New Fairfield CT Mario G. Cardozo - Brookfield CT Christine Anne Grygon - Redding CT Rachel Rebecca Kroe - Bethel CT John Robert Proudfoot - Newtown CT
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT
International Classification:
C12Q 134
US Classification:
435 18, 435 4, 435968
Abstract:
This invention is directed to a fluorescence polarization assay useful in the detection and evaluation of soluble epoxide hydrolase (sEH) inhibitors. This invention also relates to novel fluorescent probes used in the fluorescence polarization assay, and methods of manufacturing such fluorescent probes. This fluorescent probe of the invention is a compound having the following formula (I): wherein X is the radical of compound that binds to the active site of soluble epoxide hydrolase, Y is a fluorescent label, and âspacerâ and R are as defined herein.
Method Of Using Soluble Epoxide Hydrolase Inhibitors
Richard H. Ingraham - New Fairfield CT John R. Proudfoot - Newtown CT
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT
International Classification:
A61K 31444
US Classification:
5142372, 514333, 544131, 546256
Abstract:
Disclosed are novel compounds of the formula Ia and methods of using soluble epoxide hydrolase (sEH) inhibitors of the formulas I and Ia for diseases related to cardiovascular disease.
Methods Of Using Soluble Epoxide Hydrolase Inhibitors
Charles Cywin - Bethel CT, US Stephane De Lombaert - Madison CT, US Anne Eldrup - Danbury CT, US Richard Ingraham - New Fairfield CT, US Fariba Soleymanzadeh - Danbury CT, US Steven Taylor - Southbury CT, US Mario Cardozo - San Francisco CA, US
I put it in juices for him, said Richard Ingraham, a personal chef for Wade and his longtime girlfriend, Gabrielle Union. He does a juice now that I make out of beets, chlorophyll, ginger. Im giving him a nature-made Red Bull. Its all about giving him energy and keeping him as healthy as possib