Richard C Ivey

US Patent:

20130052668, Feb 28, 2013

Filed:

Apr 29, 2011

Appl. No.:

13/695262

Inventors:

Amanda G. Paulovich - Seattle WA, US
Richard G. Ivey - Federal Way WA, US

International Classification:

G01N 33/566
C12M 1/34
G01N 33/53

US Classification:

435 792, 436501, 435 79, 422 69, 4352872

Abstract:

The present invention provides methods, reagents, kits and devices for carrying out a diagnostic assay for use in assessing the exposure to ionizing radiation in a biological sample of interest.

US Patent:

20130052669, Feb 28, 2013

Filed:

Apr 29, 2011

Appl. No.:

13/695268

Inventors:

Amanda G. Paulovich - Seattle WA, US
Richard G. Ivey - Federal Way WA, US

International Classification:

G01N 33/566
G01N 33/53

US Classification:

435 792, 435 79, 436501

Abstract:

In one aspect, the invention provides a kit for detecting the presence or amount of a target modified protein within a sample. The kit comprises (i) a capture reagent that specifically binds to a first epitope on the target protein; (ii) at least one detection reagent that specifically binds to a second epitope on the target protein; and (iii) at least one synthetic hybrid reference peptide comprising the first epitope and the second epitope from the target protein of interest, wherein the synthetic reference peptide is capable of simultaneously binding to both the capture reagent and the at least one detection reagent, and wherein at least one of the first and second epitopes comprises a modified amino acid residue.