Richard G Macdonald

US Patent:

6730517, May 4, 2004

Filed:

Oct 5, 2000

Appl. No.:

09/680581

Inventors:

Ping Yip - San Diego CA
Jhobe Steadman - San Diego CA
Dirk Reuter - Hamburg, DE
Richard MacDonald - San Diego CA

Assignee:

Sequenom, Inc. - San Diego CA

International Classification:

G01N 3502

US Classification:

436 47, 436 43, 436173, 436131, 422 63, 422 65, 422 67, 422102, 250251, 250282, 250287, 250288, 700266

Abstract:

Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

US Patent:

20020009394, Jan 24, 2002

Filed:

Apr 2, 1999

Appl. No.:

09/285481

Inventors:

HUBERT KOSTER - LA JOLLA CA, US
PING YIP - SAN DIEGO CA, US
JHOBE STEADMAN - SAN DIEGO CA, US
DIRK REUTER - HAMBURG, DE
RICHARD MACDONALD - SAN DIEGO CA, US

International Classification:

G01N035/00

US Classification:

422/065000, 436/043000, 436/047000, 436/181000, 422/067000

Abstract:

A fully automated modular analytical system integrates instrumentation to permit analysis of biopolymer samples. The samples include, but are not limited to, all biopolymers, e.g., nucleic acids, proteins, peptides and carbohydrates. The system integrates analytical methods of detection and analysis, e.g., mass spectrometry, radiolabeling, mass tags, chemical tags, fluorescence chemiluminescence, and the like, with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

US Patent:

48777374, Oct 31, 1989

Filed:

Sep 6, 1985

Appl. No.:

6/773430

Inventors:

Meng-Fu Shih - San Diego CA
Mark D. Cochran - La Jolla CA
Richard D. Macdonald - San Diego CA

Assignee:

PruTech Research and Development Partnership - San Jose CA

International Classification:

C12N 700

US Classification:

435235

Abstract:

Attenuated pseudorabies viruses are provided which comprise DNA including a sequence essential for replication of the attenuated virus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring pseudorabies virus, from which at least a portion of a repeat sequence has been deleted. These viruses are useful as vaccines for immunizing animals against pseudorabies virus disease. The invention also provides methods of preparing attenuated pseudorabies viruses.

US Patent:

58307451, Nov 3, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/467747

Inventors:

Lisa J. Hock - La Jolla CA
Mark D. Cochran - Carlsbad CA
Richard D. Macdonald - San Diego CA

Assignee:

Syntro Corporation - Lenexa KS

International Classification:

C12N 701
C12N 1500
C12N 1511
C12N 1586

US Classification:

4352351

Abstract:

The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e. g. , a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.

US Patent:

52738760, Dec 28, 1993

Filed:

Oct 16, 1990

Appl. No.:

7/599270

Inventors:

Lisa J. Hock - La Jolla CA
Mark D. Cochran - Carlsbad CA
Richard D. Macdonald - San Diego CA

Assignee:

Syntro Corporation - Lenexa KS

International Classification:

C12N 701
C12N 1586
C12N 938
C12P 2100

US Classification:

4352351

Abstract:

The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e. g. , a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.

US Patent:

55610633, Oct 1, 1996

Filed:

Dec 9, 1993

Appl. No.:

8/164220

Inventors:

Lisa J. Hock - La Jolla CA
Mark D. Cochran - Carlsbad CA
Richard D. Macdonald - San Diego CA

Assignee:

Syntro Corporation - Lenexa KS

International Classification:

C12N 1586
C12N 701
C12N 1500
C12N 1511

US Classification:

4353201

Abstract:

The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e. g. , a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.

US Patent:

20180034654, Feb 1, 2018

Filed:

Jul 24, 2017

Appl. No.:

15/658315

Inventors:

- San Diego CA, US
Robert M. McGraw - Del Mar CA, US
Richard A. MacDonald - San Diego CA, US

International Classification:

H04L 12/18
H04W 12/02
H04W 12/06

Abstract:

An automated method that generates crowd-sourced event notifications includes: retrieving sensor data from mobile devices; detecting events based on the retrieved sensor data; and generating a set of summary nodes based on the events, where each summary node is associated with multiple events. A system that generates crowd-sourced event notifications includes: multiple mobile devices, each having at least one sensor, each mobile device identifies events using calculations based on sensor data and generates a notification for each identified event; and an analytics server that generates a set of summary nodes based on the identified events, each summary node associated with multiple events. An automated method that generates event notifications includes: retrieving sensor data; calculating a set of statistical values based on the sensor data; comparing the statistical values to at least one threshold; and generating an event notification when the threshold is exceeded by any of the statistical values.