Richard A Mickelsen

US Patent:

20020028260, Mar 7, 2002

Filed:

Aug 1, 2001

Appl. No.:

09/920511

Inventors:

Edward Walker - Ogden UT, US
Richard Mickelsen - Ogden UT, US
Jennifer Mickelsen - Ogden UT, US

International Classification:

A61K035/78

US Classification:

424/766000, 424/732000

Abstract:

Compounds isolated from plant materials, particularly plants of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, and an extract of such plant materials which is significantly enriched for the anti-adhesion activity. The specific compounds include procyanidins (also known as “condensed tannins”), leukocyanin, leucodelphinin, flavonol glucosides including myricetin-3-pyranoside and proanthocyanidin extracts. These proanthocyanidin extracts are capable of inhibiting agglutination reactions of P-type The extracts containing proanthocyanidins contain at least one A-type interflavanoid bond. Methods of making an extract. Methods of preventing or treating urogenital infections in a mammal by administering a proanthocyanidin composition including the proanthocyanidin extract, a proanthocyanidin compound, a proanthocyanidin polymer or a mixture thereof, to a subjecct in an amount and for a time sufficient to prevent, reduce or eliminate symptoms associated with such infections.

US Patent:

62106813, Apr 3, 2001

Filed:

Sep 7, 1999

Appl. No.:

9/391308

Inventors:

Edward B. Walker - Ogden UT
Richard A. Mickelsen - Ogden UT
Jennifer N. Mickelsen - Ogden UT

Assignee:

JLB, Inc. - Ogden UT

International Classification:

A01N 6500
A61K 3578
A61K 39385

US Classification:

4241951

Abstract:

Compounds isolated from plant materials, particularly plants of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, and an extract of such plant materials which is significantly enriched for the anti-adhesion activity. The specific compounds include procyanidins (also known as "condensed tannins"), leukocyanin and leucodelphinin, and flavonol glucosides including myricetin-3-pyranoside and proanthocyanidin extracts. These proanthocyanidin extracts are capable of inhibiting agglutination reactions of P-type E. coli. The extracts containing proanthocyanidins contain at least one A-type interflavanoid bond. Methods of making an extract having the properties. Methods of preventing or treating urogenital infections in a mammal by administering a proanthocyanidin composition including the proanthocyanidin extract, a proanthocyanidin compound, a proanthocyanidin polymer or a mixture thereof, to the mammal in an amount and for a time sufficient to prevent, reduce or eliminate the symptoms associated with such infections and thereby lead to an amelioration or curing of the infection.

US Patent:

55253415, Jun 11, 1996

Filed:

Feb 1, 1994

Appl. No.:

8/189889

Inventors:

Edward B. Walker - Ogden UT
Richard A. Mickelsen - Ogden UT
Jennifer N. M. Ickelsen - Ogden UT
Brent L. Roth - Ogden UT

Assignee:

JLB, Inc. - Ogden UT

International Classification:

A61K 3578

US Classification:

4241951

Abstract:

An extract prepared from plants of the genus Vaccinium, especially cranberries, which is enriched for an activity which inhibits bacterial adhesion to surfaces. The extract is also enriched for polyphenol and flavonoid compounds, lacks detectable amounts of simple sugars, has a very low content of benzoic acid relative to raw cranberries, and lacks significant amounts of anthocyanins. Methods for preparing and for using the extract are also disclosed.

US Patent:

56504322, Jul 22, 1997

Filed:

Mar 24, 1995

Appl. No.:

8/409703

Inventors:

Edward B. Walker - Ogden UT
Richard A. Mickelsen - Ogden UT
Jennifer N. Mickelsen - Ogden UT

Assignee:

JLB, Inc. - Ogden UT

International Classification:

A61K 3135
A61K 31045
A61K 3578

US Classification:

514456

Abstract:

Proanthocyanidin monomers, dimers, polymers, flavonoid, and flavanoid derivatives and related compounds are used for their ability to interfere with bacterial adherence to a surface. Crystalline proanthocyanadin dimer and plant extracts enriched with such compounds are also disclosed.

US Patent:

56461780, Jul 8, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/473864

Inventors:

Edward B. Walker - Ogden UT
Richard A. Mickelsen - Ogden UT
Jennifer N. Mickelsen - Ogden UT

Assignee:

JLB, Inc. - Ogden UT

International Classification:

A61K 3116
A61K 31045
A61K 31725
A61K 3578

US Classification:

514456

Abstract:

Compounds isolated from plant materials of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, are described. The specific compounds include procyanidins, leucocyanin and leucodelphinin, and flavonol glucosides including myricetin-3-pyranoside. An exemplary procyanidin compound is a substituted epicatechin-catechin dimer or other polymer. Also described is an extract prepared from plants of the genus Vaccinium, especially cranberries, which is enriched for anti-adhesion activity. The extract is enriched for polyphenol and flavonoid compounds, lacks detectable amounts of simple sugars, has a very low content of benzoic acid relative to raw cranberries, and lacks significant amounts of anthocyanins. Methods for preparing and for using the extract are disclosed.

US Patent:

20010021398, Sep 13, 2001

Filed:

Mar 30, 2001

Appl. No.:

09/822710

Inventors:

Edward Walker - Ogden UT, US
Richard Mickelsen - Ogden UT, US
Jennifer Mickelsen - Ogden UT, US

International Classification:

A61K035/78

US Classification:

424/732000, 424/766000

Abstract:

Compounds isolated from plant materials, particularly plants of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, and an extract of such plant materials which is significantly enriched for the anti-adhesion activity. The specific compounds include procyanidins (also known as “condensed tannins”), leukocyanin, leucodelphinin, flavonol glucosides including myricetin-3-pyranoside and proanthocyanidin extracts. These proanthocyanidin extracts are capable of inhibiting agglutination reactions of P-type . The extracts containing proanthocyanidins contain at least one A-type interflavanoid bond. Methods of making an extract. Methods of preventing or treating urogenital infections in a mammal by administering a proanthocyanidin composition including the proanthocyanidin extract, a proanthocyanidin compound, a proanthocyanidin polymer or a mixture thereof, to a subject in an amount and for a time sufficient to prevent, reduce or eliminate symptoms associated with such infections.