Richard Lee Nuccitelli

US Patent:

8597187, Dec 3, 2013

Filed:

Jun 15, 2009

Appl. No.:

12/484971

Inventors:

Richard Lee Nuccitelli - Millbrae CA, US
Pamela Nuccitelli - Millbrae CA, US
Suman Narsing - Herndon VA, US
Brian Athos - Pleasanton CA, US
Saleh Sheikh - Hampton VA, US

Assignee:

BioElectroMed Corp. - Burlingame CA

International Classification:

A61B 5/103

US Classification:

600306, 600300

Abstract:

The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

US Patent:

20050154270, Jul 14, 2005

Filed:

Jan 7, 2005

Appl. No.:

11/031188

Inventors:

Richard Nuccitelli - Norfolk VA, US
Richard Sanger - Woods Hole MA, US
Peter Smith - Falmouth MA, US

International Classification:

A61B005/05

US Classification:

600345000

Abstract:

A system and method is disclosed for obtaining measurements of the electric fields around skin wounds and lesions on mammals noninvasively. The system and method is comprised of a vibrating metallic probe tip that is placed close to the skin in the air. By applying a series of known voltages to the metal probe tip or to the skin beneath it, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Surface artifacts that can affect the measurements are removed and active feedback is used to maintain a constant distance between the probe and the skin surface.

US Patent:

20090281411, Nov 12, 2009

Filed:

May 8, 2008

Appl. No.:

12/117598

Inventors:

Richard Nuccitelli - Millbrae CA, US
Pamela Nuccitelli - Millbrae CA, US
Uwe F. Pliquett - Heilbad Heiligenstadt, DE
Changyi Li - Laurel MD, US
Suman Narsing - Herndon VA, US
Brian Athos - Pleasanton CA, US
Saleh Sheikh - Hampton VA, US

Assignee:

BioElectroMed Corp. - Burlingame CA

International Classification:

A61B 5/05

US Classification:

600407

Abstract:

The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

US Patent:

20100240995, Sep 23, 2010

Filed:

Mar 17, 2010

Appl. No.:

12/726037

Inventors:

Richard Lee NUCCITELLI - Millbrae CA, US
Pamela NUCCITELLI - Millbrae CA, US
Saleh SHEIKH - Hampton VA, US
Kevin Tran - San Jose CA, US
Brian Athos - Pleasanton CA, US
Mark Kreis - San Francisco CA, US

Assignee:

BIOELECTROMED CORP. - Burlingame CA

International Classification:

A61B 18/14
A61B 8/00

US Classification:

600439, 606 41

Abstract:

Systems and methods for treating tumors on or within internal organs of mammals that have been imaged with endoscopic ultrasound are described. The system uses an expandable bipolar electrode assembly that can be imaged by ultrasound and can penetrate, e.g., the stomach, intestine or bowel wall, etc. and be positioned in or around the tumor on an internal organ while being guided by an operator who visualizes its position with ultrasound imaging. It utilizes an electrode assembly that extends down an internal cavity in the endoscope to allow the operator to spread the electrodes for pulse delivery of a nanosecond pulsed electric field (nsPEF) to the tumor.

US Patent:

20100318082, Dec 16, 2010

Filed:

Mar 11, 2010

Appl. No.:

12/722441

Inventors:

Richard Lee NUCCITELLI - Millbrae CA, US
Pamela NUCCITELLI - Millbrae CA, US
Saleh SHEIKH - Hampton VA, US
Kevin TRAN - San Jose CA, US
Brian Athos - Pleasanton CA, US
Mark KREIS - San Francisco CA, US

Assignee:

BIOELECTROMED CORP. - Burlingame CA

International Classification:

A61B 18/04

US Classification:

606 41

Abstract:

Nanosecond pulsed electric field (nsPEF) parameters for destroying tumors with a single treatment are described. A nsPEF generator may be used with an electrode assembly to apply the pulses to one or more tumors where the parameters for the nsPEF are optimized for treating such tumors.

US Patent:

20110009929, Jan 13, 2011

Filed:

May 9, 2008

Appl. No.:

12/599259

Inventors:

Richard L. Nuccitelli - Burlingame CA, US
Uwe F. Pliquett - Heilbad Heiligenstadt, DE
Pamela Nuccitelli - Burlingame CA, US
Changyi Li - Norfolk VA, US
Saleh H. Sheikh - Norfolk VA, US

International Classification:

A61N 1/04

US Classification:

607 72, 607 2

Abstract:

A medical instrument for delivering electrotherapy is provided. The instrument includes an outer support member having an open distal end and a base wall portion within the support member arranged to form a cup-like volume at the distal end. The instrument also includes at least one aperture formed in the cup-like volume for applying a suction to the cup-like region. The instrument further includes a first and a second electrode having at least a portion within the cup region or proximate to the cup region for providing an electric field in the cup region when a bias signal is applied between the first and second electrodes.

US Patent:

20110092973, Apr 21, 2011

Filed:

Feb 26, 2007

Appl. No.:

12/280280

Inventors:

Richard Nuccitelli - Norfolk VA, US
Stephen J. Beebe - Norfolk VA, US
Karl H. Schoenbach - Norfolk VA, US

Assignee:

EASTERN VIRGINIA MEDICAL SCHOOL - Norfolk VA
OLD DOMINION UNIVERSITY - Norfolk VA

International Classification:

A61B 18/00

US Classification:

606 49, 606 41

Abstract:

Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.

US Patent:

20210401489, Dec 30, 2021

Filed:

Mar 20, 2020

Appl. No.:

17/041420

Inventors:

- Hayward CA, US
Darrin R. UECKER - San Mateo CA, US
Richard L. NUCCITELLI - Millbrae CA, US

International Classification:

A61B 18/14
A61B 34/10
A61B 34/20
A61B 34/32
A61B 18/20

Abstract:

Described herein are methods and apparatuses for the application of electric energy treatment(s) to skin tissue to alter pigmentation, and in particular to remove a tattoo. These methods and apparatuses may deliver pulsed electrical energy having a pulse duration in submicrosecond pulse range to provide high-field strength pulses that may effectively release tattoo ink and allow removal of tattoo ink regardless of ink color or composition.