Richard A Partyka

US Patent:

52063607, Apr 27, 1993

Filed:

Apr 17, 1992

Appl. No.:

7/870017

Inventors:

Thomas W. Hudyma - Durham CT
Richard A. Partyka - Killingworth CT

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C07D50118

US Classification:

540205

Abstract:

A compound of formula I ##STR1## wherein X is sulfur or CH. sub. 2 ; R. sup. 1 is hydrogen, hydroxy, amino, C. sub. 1-6 alkyl, C. sub. 2-6 alkenyl, C. sub. 2-6 alkynyl, phenyl optionally substituted with one to three C. sub. 1-6 alkyl, C. sub. 1-6 alkyloxy or hydroxy, C. sub. 1-6 alkylthio, phenylthio optionally substituted with one to three C. sub. 1-6 alkyl or C. sub. 1-6 alkyloxy on the phenyl ring, phenylmethyloxy optionally substituted with one to three C. sub. 1-6 alkyl or C. sub. 1-6 alkyloxy on the phenyl ring, 1-morpholino, C. sub. 1-6 alkyloxy, C. sub. 2-6 alkenylmethyloxy, C. sub. 3-6 alkynylmethyloxy, C. sub. 1-6 alkylamino, C. sub. 1-6 dialkylamino or a radical selected from the group consisting of ##STR2## in which n is 0 to 3, R. sup. 5 is C. sub. 1-6 alkyl or hydrogen, and R. sup. 3 and R. sup. 4 are independently C. sub.

US Patent:

51068427, Apr 21, 1992

Filed:

Oct 22, 1990

Appl. No.:

7/600656

Inventors:

Thomas W. Hudyma - Durham CT
Richard A. Partyka - Killingworth CT

Assignee:

Bristol-Myers Squibb Co. - New York NY

International Classification:

C07D50124
A61K 31545

US Classification:

514202

Abstract:

A compound of formula I ##STR1## wherein X is sulfur or CH. sub. 2 ; R. sup. 1 is hydrogen, hydroxy, amino, C. sub. 1-6 alkyl, C. sub. 2-6 alkenyl, C. sub. 2-6 alkynyl, phenyl optionally substituted with one to three C. sub. 1-6 alkyl, C. sub. 1-6 alkyloxy or hydroxy, C. sub. 1-6 alkylthio, phenylthio optionally substituted with one to three C. sub. 1-6 alkyl or C. sub. 1-6 alkyloxy on the phenyl ring, phenylmethyloxy optionally substituted with one to three C. sub. 1-6 alkyl or C. sub. 1-6 alkyloxy on the phenyl ring, 1-morpholino, C. sub. 1-6 alkyloxy, C. sub. 2-6 alkenylmethyloxy, C. sub. 3-6 alkynylmethyloxy, C. sub. 1-6 alkylamino, C. sub. 1-6 dialkylamino or a radical selected from the group consisting of ##STR2## in which n is 0 to 3, R. sup. 5 is C. sub. 1-6 alkyl or hydrogen, and R. sup. 3 and R. sup. 4 are independently C. sub.

US Patent:

51698439, Dec 8, 1992

Filed:

Dec 23, 1991

Appl. No.:

7/879408

Inventors:

Thomas W. Hudyma - Durham CT
Richard A. Partyka - Killingworth CT

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C07D47104
A61K 31435

US Classification:

514210

Abstract:

A compound for formula I ##STR1## wherein X is sulfur or CH. sub. 2 ; R. sup. 1 is hydrogen, hydroxy, amino, C. sub. 1-6 alkyl, C. sub. 2-5 alkenyl, C. sub. 2-6 alkynyl, phenyl optionally substituted with one to three C. sub. 1-6 alkyl, C. sub. 1-6 alkyloxy or hydroxy, C. sub. 1-6 alkylthio, phenylthio optionally substituted with one to three C. sub. 1-6 alkyl or C. sub. 1-6 alkyloxy on the phenyl ring, phenylmethyloxy optionally substituted with one to three C. sub. 1-6 alkyl or C. sub. 1-6 alkyloxy on the phenyl ring, 1-morpholino, C. sub. 1-6 alkyloxy, C. sub. 2-6 alkenylmethyloxy, C. sub. 3-6 alkynylmethyloxy, C. sub. 1-6 alkylamino, C. sub. 1-6 dialkylamino or a radical selected from the group consisting of ##STR2## in which n is 0 to 3, R. sup. 5 is C. sub. 1-6 alkyl or hydrogen, and R. sup. 3 and R. sup. 4 are independently C. sub.