Richard N Pierson

US Patent:

8134354, Mar 13, 2012

Filed:

Mar 3, 2009

Appl. No.:

12/396975

Inventors:

Benjamim Tang - Ranchos Palos Verdes CA, US
Robert T. Carroll - Andover MA, US
Scott W. Southwell - Seal Beach CA, US
Kenneth A. Ostrom - Palos Verdes Estates CA, US
Richard C. Pierson - Newport Beach CA, US

International Classification:

G05F 1/59

US Classification:

323283, 323272, 323284

Abstract:

Disclosed is a multi-phase pulse width modulated voltage regulator and method in which transient voltage excursions or deviations that exceed the load line voltage by more than a predetermined amount are detected by an ATR circuit and a correction signal is applied. The correction signal is in the form of asynchronous pulses and the number of such pulses is a function of the magnitude of the voltage excursion as determined by the number of thresholds that are exceeded. Also disclosed is an adaptive voltage positioning (AVP) circuit and method for early detection of a transient event by sensing voltage changes at the load and adjusting the target voltage with pre-determined current values prior to the time that ATR event changes in the current at the load are detected. The AVP load line is pre-positioned for more precise current control. Also disclosed is an adaptive filter with adjustable frequency characteristics in response to an ATR event.

US Patent:

20030144358, Jul 31, 2003

Filed:

Dec 2, 2002

Appl. No.:

10/307813

Inventors:

Richard Pierson - Nashville TN, US
George Zorn - Nashville TN, US
Todd Giorgio - Nashville TN, US
Simon Robson - Weston MA, US
Agnes Azimzadeh - Brentwood TN, US

International Classification:

A61K031/195

US Classification:

514/564000

Abstract:

A method of inhibiting complement activation, particularly by a transplanted tissue, in a warm-blooded vertebrate. The method includes administering a therapeutically effective amount of a platelet activity modulator to a warm-blooded vertebrate before, during or after a tissue is transplanted to the warm-blooded vertebrate, whereby complement activation by the transplanted tissue is inhibited. The platelet activity modulator can include a combination of a GPIb modulator and a GPIIb/GPIIIa modulator.

US Patent:

20180146660, May 31, 2018

Filed:

Jun 3, 2016

Appl. No.:

15/577445

Inventors:

- Baltimore MD, US
Agnes M. Azimzadeh - Timonium MD, US
Richard N. Pierson III - Ruxton MD, US

International Classification:

A01N 1/02
A61K 38/36
A61K 35/14
A61K 36/48

Abstract:

The present invention relates to the use of activated Protein C (aPC) to enhance the viability of transplant graft. In certain instances, the invention provides methods of ex vivo perfusion of transplant graft with a composition comprising aPC.