Richard G Preston

US Patent:

20120201809, Aug 9, 2012

Filed:

Nov 28, 2011

Appl. No.:

13/305354

Inventors:

Abhijit Suresh Bhat - Encinitas CA, US
Curt William Bradshaw - San Diego CA, US
Olivier Alexandre Laurent - San Diego CA, US
Alice Lee - Poway CA, US
Richard Ryan Preston - Escondido CA, US
David Tumelty - San Diego CA, US
Lauren Diane Wood - San Diego CA, US
Wei Hong Yu - San Diego CA, US

Assignee:

COVX TECHNOLOGIES IRELAND, LIMITED - Dun Laoghaire

International Classification:

A61K 39/395
A61P 9/00
A61P 35/00
C07K 16/00

US Classification:

4241331, 5303917, 4241781

Abstract:

The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising Kaccording to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety.The invention further provides specific MAC compounds and compositions of the invention.

US Patent:

20130323234, Dec 5, 2013

Filed:

Jan 7, 2013

Appl. No.:

13/736029

Inventors:

ALICE LEE - Poway CA, US
RICHARD RYAN PRESTON - Escondido CA, US
DAVID TUMELTY - San Diego CA, US
WEI HONG YU - San Diego CA, US
ABHIJIT SURESH BHAT - Encinitas CA, US

Assignee:

COVX TECHNOLOGIES IRELAND LIMITED - Ringaskiddy

International Classification:

C07K 16/46
C07K 16/30

US Classification:

4241331, 5303873, 5303919, 536 2353, 4353201, 435328

Abstract:

The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X-X-X-X-KH(SEQ ID NO:98), and X, Xand Xare each independently any amino acid residue, characterized in that Xis selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof

US Patent:

20210147576, May 20, 2021

Filed:

Jun 9, 2020

Appl. No.:

16/896930

Inventors:

- Dublin, IE
Alice Lee - Poway CA, US
Richard Ryan Preston - Escondido CA, US
David Tumelty - San Diego CA, US
Wei Hong Yu - San Diego CA, US
Abhijit Suresh Bhat - Encinitas CA, US

International Classification:

C07K 16/46
A61K 39/395
C07K 16/28
C07K 14/415
C12N 9/00
C07K 16/32
C07K 16/00
A61K 47/68
C07K 16/30

Abstract:

The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X-X-X-X-KH(SEQ ID NO:98), and X, Xand Xare each independently any amino acid residue, characterized in that Xis selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof