Richard Robinson Richardson

US Patent:

20100286280, Nov 11, 2010

Filed:

Sep 23, 2008

Appl. No.:

12/680339

Inventors:

Michael G. O'Rand - Chapel Hill NC, US
Esther Elaine Widgren - Chapel Hill NC, US
Richard Richardson - Durham NC, US
Brenda Temple - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 31/16
A61P 15/16

US Classification:

514616

Abstract:

Compounds suitable for use in providing male contraception, an assay method for identifying such compounds, and methods of providing contraception using the compounds, are provided. The compounds described herein inhibit Eppin-semenogelin binding, and inhibit forward motility of sperm in humans and other primates. The assays identify compounds which both inhibit eppin-semenogelin binding and inhibit sperm motility, and can be carried out in a high throughput manner, using labeled recombinant Eppin and semenogelin. The compounds can be used in oral or transdermal compositions to temporarily and reversibly inhibit male fertility. They can also be used in addition to, or in place of, spermicides in spermicidal compositions, such as those used in conjunction with condoms, diaphragms, and spermicidal jellies.

US Patent:

58208615, Oct 13, 1998

Filed:

May 8, 1995

Appl. No.:

8/436883

Inventors:

Michael G. O'Rand - Chapel Hill NC
Esther E. Widgren - Chapel Hill NC
Richard T. Richardson - Chapel Hill NC
Isabel A. Lea - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 3800

US Classification:

4241841

Abstract:

The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.

US Patent:

56163223, Apr 1, 1997

Filed:

May 8, 1995

Appl. No.:

8/436793

Inventors:

Michael G. O'Rand - Chapel Hill NC
Esther E. Widgren - Chapel Hill NC
Richard T. Richardson - Chapel Hill NC
Isabel A. Lea - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 3900

US Classification:

4241921

Abstract:

The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigeenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.

US Patent:

58144560, Sep 29, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/436772

Inventors:

Michael G. O'Rand - Chapel Hill NC
Esther E. Widgren - Chapel Hill NC
Richard T. Richardson - Chapel Hill NC
Isabel A. Lea - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

G01N 3353
G01N 33536
G01N 33535
G01N 33564

US Classification:

435 71

Abstract:

The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.

US Patent:

54807999, Jan 2, 1996

Filed:

Dec 10, 1993

Appl. No.:

8/166195

Inventors:

Michael G. O'Rand - Chapel Hill NC
Esther E. Widgren - Chapel Hill NC
Richard T. Richardson - Chapel Hill NC
Isabel A. Lea - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12N 121
C12N 1512
C12N 119
C12N 510

US Classification:

4352523

Abstract:

The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigeenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.