Richard A Roth

US Patent:

7510835, Mar 31, 2009

Filed:

Nov 25, 2003

Appl. No.:

10/723681

Inventors:

Richard B. Roth - La Jolla CA, US
Matthew Roberts Nelson - San Marcos CA, US
Stefan M. Kammerer - San Diego CA, US
Andreas Braun - San Diego CA, US
Rikard Reneland - San Diego CA, US

Assignee:

Sequenom, Inc. - San Diego CA

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04
C07H 21/02

US Classification:

435 6, 435 911, 435 912, 536 231, 536 243

Abstract:

Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

US Patent:

20030148974, Aug 7, 2003

Filed:

Jun 21, 2002

Appl. No.:

10/168771

Inventors:

Brett Monia - Encinitas CA, US
Lex Cowsert - San Mateo CA, US
Richard Roth - Stanford CA, US

International Classification:

C07H021/04
A61K048/00

US Classification:

514/044000, 536/023200

Abstract:

Antisense compounds, compositions and methods are provided for modulating the expression of Akt-3. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding Akt-3. Methods of using these compounds for modulations of Akt-3 expression and for treatment of diseases associated with expression of Akt-3 are provided.

US Patent:

20040018533, Jan 29, 2004

Filed:

Jun 4, 2003

Appl. No.:

10/455552

Inventors:

Gail Adam - Knivsta, SE
Maria Langdown - La Jolla CA, US
Richard Roth - La Jolla CA, US
Mikhail Denissenko - Poway CA, US
Kevin Smylie - San Diego CA, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Provided herein are methods for prognosing and diagnosing fat deposition and related disorders (e.g., obesity and non-insulin diabetes dependent mellitus (NIDDM)) in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for reducing fat deposition and related disorders, and therapeutic methods for reducing fat deposition or treating fat deposition related disorders in a subject. These embodiments are based in part upon an analysis of polymorphic variations of the nucleic acid set forth in SEQ ID NO:1.

US Patent:

20050053958, Mar 10, 2005

Filed:

Nov 25, 2003

Appl. No.:

10/723142

Inventors:

Richard Roth - La Jolla CA, US
Matthew Nelson - San Marcos CA, US
Stefan Kammerer - San Diego CA, US
Andreas Braun - San Diego CA, US
Rikard Reneland - San Diego CA, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

US Patent:

20050064440, Mar 24, 2005

Filed:

Nov 6, 2003

Appl. No.:

10/703789

Inventors:

Richard Roth - La Jolla CA, US
Matthew Nelson - San Marcos CA, US
Stefan Kammerer - San Diego CA, US
Andreas Braun - San Diego CA, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

Provided herein are methods for identifying a subject at risk of melanoma and risk of melanoma in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, and therapeutic methods for treating melanoma in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

US Patent:

20050064442, Mar 24, 2005

Filed:

Nov 25, 2003

Appl. No.:

10/723518

Inventors:

Richard Roth - La Jolla CA, US
Josephine Atienza - La Jolla CA, US
Mikhail Denissenko - Poway CA, US
Andreas Braun - San Diego CA, US
Stefan Kammerer - San Diego CA, US
Matthew Nelson - San Marcos CA, US
Rikard Reneland - San Diego CA, US

International Classification:

C12Q001/68
G01N033/574

US Classification:

435006000, 435007230

Abstract:

Provided herein are methods for identifying a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

US Patent:

20050118117, Jun 2, 2005

Filed:

Nov 6, 2003

Appl. No.:

10/703817

Inventors:

Richard Roth - La Jolla CA, US
Matthew Nelson - San Marcos CA, US
Stefan Kammerer - San Diego CA, US
Andreas Braun - San Diego CA, US

International Classification:

C12Q001/68
A61K038/16
A61K048/00
A61K033/24
A61K031/4745

US Classification:

424059000, 514044000, 435006000, 514008000, 514283000, 424649000

Abstract:

Provided herein are methods for identifying risk of melanoma in a subject and/or subjects at risk of melanoma, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, therapeutic methods for treating melanoma in a subject and compositions comprising one or more melanoma cells and one or more NRP1, NID2 or ENDO180 directed agents. These embodiments are based upon an analysis of polymorphic variations in a NRP1, NID2 or ENDO180 nucleic acid, exemplified by nucleotide sequences of SEQ ID NO: 1, 2 or 3.

US Patent:

20050118606, Jun 2, 2005

Filed:

Nov 25, 2003

Appl. No.:

10/723670

Inventors:

Richard Roth - La Jolla CA, US
Caridad Rosette - San Diego CA, US
Mikhail Denissenko - Poway CA, US
Matthew Nelson - San Marcos CA, US
Rikard Reneland - San Diego CA, US
Andreas Braun - San Diego CA, US
Stefan Kammerer - San Diego CA, US

International Classification:

C12Q001/68
A61K048/00

US Classification:

435006000, 514044000

Abstract:

Provided herein are methods for identifying a risk of cancer in a subject and/or a subject at risk of cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating cancer, and therapeutic methods for treating cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in a KLF12 nucleic acid, which has a nucleotide sequence exemplified in SEQ ID NO: 1, 2 or 3.