Richard Spaete - Belmont CA Winthrop T. Jackman - Berkeley CA
Assignee:
Aviron - Burlingame CA
International Classification:
A61K 39245
US Classification:
4242301, 435 693, 4241861
Abstract:
Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
Provided are novel Toledo and Towne human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for preventing HCMV infections.
Richard Spaete - Redwood City CA Winthrop Jackman - Berkeley CA
Assignee:
MedImmune Vaccines, Inc. - Mountain View CA
International Classification:
A61K 39245
US Classification:
4241861, 4242301, 4352351
Abstract:
Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
Methods And Compositions For Controlling Translation Of Hcv Proteins
Jang H. Han - Lafayette CA, US Richard R. Spaete - Belmont CA, US Byoung J. Yoo - Lafayette CA, US Byung S. Suh - Lafayette CA, US Mark J. Selby - San Francisco CA, US Michael Houghton - Danville CA, US
Embodiments of the present invention feature methods and compositions for controlling the translation of viral peptides and proteins from viral nucleic acid, with particular applications to pestivirus and HCV. The methods and compositions feature control elements of the 5′UT region of the viral genome.
George Kemble - Saratoga CA, US Gregory M. Duke - Redwood City CA, US Richard Spaete - Emerald Hills CA, US
Assignee:
MedImmune Vaccines, Inc. - Mountain View CA
International Classification:
A61K 39/245 A61K 39/12 C12Q 1/70
US Classification:
4242301, 4241991, 435 5
Abstract:
A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
Richard Roger Spaete - Emerald Hills CA, US Tai-An Cha - San Ramon CA, US
Assignee:
MedImmune Vaccines, Inc. - Mountain View CA
International Classification:
A61K 39/245
US Classification:
4242301, 4242041, 435 6
Abstract:
Provided are novel Toledo and Towne human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for Preventing HCMV infections.
George Kemble - Saratoga CA, US Gregory M. Duke - Redwood City CA, US Richard Spaete - Emerald Hills CA, US
Assignee:
MedImmune, LLC - Gaithersburg MD
International Classification:
A61K 39/12 A61K 39/245 C12Q 1/70
US Classification:
4242041, 4242051, 4242301, 435 5
Abstract:
A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
George Kemble - Saratoga CA, US Gregory M. Duke - Redwood City CA, US Richard Spaete - Emerald Hills CA, US
Assignee:
MedImmune, LLC - Gaitherburg MD
International Classification:
A61K 39/12 A61K 39/245 C12Q 1/70
US Classification:
4242041, 4242051, 4242301, 435 5
Abstract:
A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.