Richard L Watson

US Patent:

20100297193, Nov 25, 2010

Filed:

Apr 28, 2010

Appl. No.:

12/769136

Inventors:

Gregory J. Archambeau - Puyallup WA, US
Anthony B. Wood - Dallas TX, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

A61K 33/00
A61K 9/14
A61P 27/02

US Classification:

424400, 424613, 977915

Abstract:

Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.

US Patent:

20110081384, Apr 7, 2011

Filed:

Apr 28, 2010

Appl. No.:

12/769323

Inventors:

GREGORY J. ARCHAMBEAU - PUYALLUP WA, US
RICHARD L. WATSON - MCPHERSON KS, US
ANTHONY B. WOOD - DALLAS TX, US

Assignee:

REVALESIO CORPORATION - TACOMA WA

International Classification:

A61K 33/00
A61K 9/00
A61P 17/02
A61P 29/00
A61P 31/04
A61P 31/00
B82Y 5/00

US Classification:

424400, 424613, 977915

Abstract:

Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating a wound to a surface tissue or a symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

US Patent:

20130252323, Sep 26, 2013

Filed:

May 24, 2013

Appl. No.:

13/902663

Inventors:

Gregory J. Archambeau - Puyallup WA, US
Richard L. Watson - McPherson KS, US

Assignee:

Revalesio Corporation - Tacoma WA

International Classification:

B01F 7/00

US Classification:

4352891, 3661703, 3661651, 3661653, 426590

Abstract:

A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.

US Patent:

20130270478, Oct 17, 2013

Filed:

Jun 21, 2013

Appl. No.:

13/924295

Inventors:

Gregory J. Archambeau - Puyallup WA, US
Richard L. Watson - Ruston WA, US

International Classification:

C09K 3/00

US Classification:

2521861

Abstract:

Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.

US Patent:

20130295144, Nov 7, 2013

Filed:

Mar 27, 2013

Appl. No.:

13/851888

Inventors:

Gregory J. Archambeau - Puyallup WA, US
Richard L. Watson - McPherson KS, US

International Classification:

A61J 3/00
A61K 33/00
A61K 9/10

US Classification:

424400, 424613

Abstract:

Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized with molecular oxygen.

US Patent:

20160030901, Feb 4, 2016

Filed:

Apr 14, 2015

Appl. No.:

14/686706

Inventors:

- TACOMA WA, US
Gregory J. Archambeau - Puyallup WA, US
Richard L. Watson - Ruston WA, US

International Classification:

B01F 5/06
B01F 7/00
B01F 3/04

Abstract:

A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.

US Patent:

20150050343, Feb 19, 2015

Filed:

Jul 21, 2014

Appl. No.:

14/336558

Inventors:

- Tacoma WA, US
Richard L. Watson - Ruston WA, US
Anthony B. Wood - Tacoma WA, US

International Classification:

A61K 33/00
A61K 31/58
A61K 9/14

US Classification:

424489, 424600

Abstract:

Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating a wound to a surface tissue or a symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

US Patent:

20150024010, Jan 22, 2015

Filed:

Jul 21, 2014

Appl. No.:

14/336307

Inventors:

- Tacoma WA, US
Anthony B. Wood - Tacoma WA, US
Richard L. Watson - Ruston WA, US

International Classification:

A61K 33/40
A01N 1/02
A61K 45/06

US Classification:

424400, 424613, 435 12

Abstract:

Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.