Richard E Wing

US Patent:

56113447, Mar 18, 1997

Filed:

Mar 5, 1996

Appl. No.:

8/611248

Inventors:

Howard Bernstein - Cambridge MA
Julie A. Straub - Winchester MA
Henry T. Brush - Somerville MA
Richard E. Wing - Cambridge MA

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61B 800

US Classification:

12866202

Abstract:

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

US Patent:

61326992, Oct 17, 2000

Filed:

Sep 22, 1998

Appl. No.:

9/158295

Inventors:

Howard Bernstein - Cambridge MA
Julie Ann Straub - Winchester MA
Henry T. Brush - Somerville MA
Richard E. Wing - Cambridge MA

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61B 813

US Classification:

424 952

Abstract:

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

US Patent:

58536981, Dec 29, 1998

Filed:

Nov 8, 1996

Appl. No.:

8/745676

Inventors:

Julie Ann Straub - Winchester MA
Edith Mathiowitz - Brookline MA
Howard Bernstein - Cambridge MA
Henry T. Brush - Somerville MA
Richard E. Wing - Bloomfield NJ

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61B 813

US Classification:

424 952

Abstract:

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.