Robert Wayne Barbee

US Patent:

7118534, Oct 10, 2006

Filed:

Sep 21, 2001

Appl. No.:

10/380347

Inventors:

Kevin R. Ward - Glenn Allen VA, US
Robert W. Barbee - Richmond VA, US
Rao R. Ivatury - Richmond VA, US
Bruce D. Spiess - Manakin-Sabot VA, US
James A. Arrowood - Richmond VA, US

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61B 5/02

US Classification:

600490, 600500, 600485

Abstract:

Central Venous Pressure (CVP) is non-invasively determined with accuracy comparable to invasive measurement techniques. To do so, curves are plotted based on non-invasively determined patient information obtained by applying a controllable variable (pressure) to a vein of interest at a non-distal point and taking certain measurements (such as pressure and volume measurements) from the patient. An example of a controllable variable is voltage applied in incremental inflation/deflation of a vascular cuff (). A curve is plotted based on datapoints (such as a volume increase curve or a volume decline curve). Pertinent, accurate CVP and/or blood volume information is obtained from the slope of the non-invasive-based curve. Accurate CVP information is provided without the risks and disadvantages of invasive measurements.

US Patent:

20090169630, Jul 2, 2009

Filed:

May 14, 2007

Appl. No.:

12/226945

Inventors:

Kevin Ward - Richmond VA, US
Gary Huvard - Richmond VA, US
Everette Carpenter - Richmond VA, US
Gurbhagat Sandhu - Richmond VA, US
Robert Barbee - Richmond VA, US
Bruce Spiess - Richmond VA, US

International Classification:

A61K 9/14
A61K 8/22
A61K 38/44
A61P 39/00

US Classification:

424489, 514714, 424 944

Abstract:

Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, HOor inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.

US Patent:

20120207793, Aug 16, 2012

Filed:

Feb 13, 2012

Appl. No.:

13/372364

Inventors:

Kevin Ward - Richmond VA, US
Gary Huvard - Richmond VA, US
Everette Carpenter - Richmond VA, US
Gurbhagat Sandhu - Richmond VA, US
Robert Barbee - Richmond VA, US
Bruce Spiess - Richmond VA, US

International Classification:

A61K 33/40
A61K 9/14
A61P 17/02
A61K 9/00

US Classification:

424400, 424616

Abstract:

Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, HOor inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.

US Patent:

20150231177, Aug 20, 2015

Filed:

Sep 12, 2014

Appl. No.:

14/484884

Inventors:

Kevin Ward - Richmond VA, US
Gary Huvard - Richmond VA, US
Everette Carpenter - Richmond VA, US
Gurbhagat Sandhu - Richmond VA, US
Robert Barbee - Richmond VA, US
Bruce Spiess - Richmond VA, US

Assignee:

VIRGINIA COMMONWEALTH UNIVERSITY - Richmond VA

International Classification:

A61K 33/40
A61K 31/17
A61K 9/50
A61K 47/06

Abstract:

Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, HOor inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.