CellOxess, NYU Langone Medical School Fertility Center
Jun 2012 to Dec 2012 Senior ScientistLong Island University
Jan 2012 to May 2012 Research AssistantMount Sina School of Medicine
Jul 2008 to Dec 2010 Postdoctoral FellowDept. of Medicine
Feb 2007 to Jun 2008 SupervisorDept. of Microbiology
Dec 2002 to Jan 2007 Development of a BACUniversity of St. Andrews, Centre for Biomolecular Sciences
Mar 1997 to Oct 1997 Research Technician
Education:
University of St. Andrews St. Andrews 1997 to 2002 PhD in ChemistryUniversity of Birmingham Birmingham 1994 MSc in ToxicologyUniversity of Edinburgh Edinburgh 1989 BSc in BiochemistryUniversity of St. Andrews Dr. C. in Research
Medical School Medical University of South Carolina College of Medicine Graduated: 1971
Procedures:
Knee Arthroscopy Shoulder Arthroscopy Arthrocentesis Carpal Tunnel Decompression Hip Replacement Hip/Femur Fractures and Dislocations Knee Replacement Lower Arm/Elbow/Wrist Fractures and Dislocations Shoulder Surgery
Conditions:
Fractures, Dislocations, Derangement, and Sprains Internal Derangement of Knee Cartilage Intervertebral Disc Degeneration Osteoarthritis Rotator Cuff Syndrome and Allied Disorders
Languages:
English
Description:
Dr. Bowles graduated from the Medical University of South Carolina College of Medicine in 1971. He works in Charleston, SC and specializes in Orthopaedic Surgery. Dr. Bowles is affiliated with Bon Secours St Francis Hospital and Roper Hospital.
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
Composite Tissue-Engineered Intervertebral Disc With Self-Assembled Annular Alignment
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
Composite Tissue-Engineered Intervertebral Disc With Self-Assembled Annular Alignment
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
Composite Tissue-Engineered Intervertebral Disc With Self-Assembled Annular Alignment
- Ithaca NY, US Roger Hartl - New York NY, US Robert D. Bowles - Ithaca NY, US Harry H. Gebhard - Tuebingen, DE
International Classification:
A61L 27/36 A61L 27/44 A61L 27/22 A61L 27/24
Abstract:
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
Youtube
Robert Bowles
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2006 Latornell Pioneer Robert Bowles
The Conservation Pioneer Award honours individuals who have contribute...