Robert B Busch

US Patent:

20090155179, Jun 18, 2009

Filed:

Sep 6, 2006

Appl. No.:

12/065890

Inventors:

Mark K. Hellerstein - Kensington CA, US
Robert Busch - Berkeley CA, US

Assignee:

KINEMED, INC. - Emeryville CA

International Classification:

A61K 49/00
A61P 35/00

US Classification:

424 92

Abstract:

The methods of the present invention allow for the measurement of proliferation, clonal expansion trafficking and/or recruitment of lymphocytes into lymphoid tissue in an in vivo setting. Proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes are measured by using stable isotopes to label newly synthesized DNA, isolating the newly-labeled DNA, and quantifying enrichment of the isolated DNA with mass spectrometry or other appropriate techniques. Such methods are useful in screening candidate drugs for stimulatory or inhibitory effects on proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes. The methods also allow for the discovery of therapeutic agents in disorders of immune regulation such as HIV infection and for optimizing vaccine efficacy.

US Patent:

54572568, Oct 10, 1995

Filed:

Jun 6, 1994

Appl. No.:

8/254850

Inventors:

Michael J. Mitariten - Peekskill NY
Robert K. Busch - Grand Island NY

Assignee:

UOP - Des Plaines IL

International Classification:

C07C 5327
F25J 306

US Classification:

585655

Abstract:

A process is disclosed for the catalytic dehydrogenation of C. sub. 3 -C. sub. 4 hydrocarbons wherein an integrated scheme comprising a cold box unit and a pressure swing adsorption unit is employed to reject methane produced in the dehydrogenation reaction from the hydrogen-rich recycle stream. The process results in a significant improvement in the efficiency of the separation of the reaction by-products and a corresponding increase in the overall feed capacity of the process.