Robert C Busch

US Patent:

20060079786, Apr 13, 2006

Filed:

Oct 11, 2005

Appl. No.:

11/249069

Inventors:

Alyse Stofer - Woodbury MN, US
Tanya Shipkowitz - St. Paul MN, US
John Yates - St. Paul MN, US
Justin Vanhee - Minneapolis MN, US
Robert Brockway - Maple Grove MN, US
Robert Busch - Taylors Falls MN, US

Assignee:

Transoma Medical, Inc. - Saint Paul MN

International Classification:

A61B 8/14

US Classification:

600465000

Abstract:

Flow probe designs that are relatively atraumatic to blood vessels and therefore are suitable for chronic implantation.

US Patent:

20090155179, Jun 18, 2009

Filed:

Sep 6, 2006

Appl. No.:

12/065890

Inventors:

Mark K. Hellerstein - Kensington CA, US
Robert Busch - Berkeley CA, US

Assignee:

KINEMED, INC. - Emeryville CA

International Classification:

A61K 49/00
A61P 35/00

US Classification:

424 92

Abstract:

The methods of the present invention allow for the measurement of proliferation, clonal expansion trafficking and/or recruitment of lymphocytes into lymphoid tissue in an in vivo setting. Proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes are measured by using stable isotopes to label newly synthesized DNA, isolating the newly-labeled DNA, and quantifying enrichment of the isolated DNA with mass spectrometry or other appropriate techniques. Such methods are useful in screening candidate drugs for stimulatory or inhibitory effects on proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes. The methods also allow for the discovery of therapeutic agents in disorders of immune regulation such as HIV infection and for optimizing vaccine efficacy.