Robert Vance Cheek

US Patent:

7846692, Dec 7, 2010

Filed:

Mar 7, 2008

Appl. No.:

12/044302

Inventors:

Robert L. Cheek - Mebane NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US

Assignee:

Tripath Imaging, Inc. - Burlington NC

International Classification:

C12P 21/04

US Classification:

435 7021, 4241841, 5303871

Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

US Patent:

8252904, Aug 28, 2012

Filed:

Mar 5, 2010

Appl. No.:

12/718693

Inventors:

Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Apex NC, US

Assignee:

Tripath Imaging, Inc. - Burlington NC

International Classification:

C07K 16/00
C07K 14/00
C07K 5/00
G01N 33/53

US Classification:

5303871, 5303879, 5303881, 530330, 530324, 530395, 435 71

Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.

US Patent:

8476033, Jul 2, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560080

Inventors:

Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Cary NC, US

Assignee:

TriPath Imaging, Inc. - Burlington NC

International Classification:

G01N 33/00
C07K 16/00

US Classification:

435 792, 435 794, 435 71, 435 72, 5303871, 5303881, 530350, 436 64

Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.

US Patent:

20110038883, Feb 17, 2011

Filed:

Oct 29, 2010

Appl. No.:

12/915200

Inventors:

Robert L. Cheek - Mebane NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US

Assignee:

TriPath Imaging, Inc - Burlington NC

International Classification:

A61K 39/00
C07K 16/18
C12N 5/16
G01N 33/53
C07K 7/06
C07K 7/08
C07K 14/00
C07H 21/04
C12P 21/06

US Classification:

4241841, 5303882, 435332, 435 71, 530327, 530325, 530326, 536 231, 435 696

Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

US Patent:

20140315283, Oct 23, 2014

Filed:

May 9, 2013

Appl. No.:

14/239894

Inventors:

David A. Calderwood - Chapel Hill NC, US
Rodolfo Rodriguez - Cary NC, US
Demetris Young - Durham NC, US
Jasper N. Pollard - Durham NC, US
Robert L. Cheek - Mebane NC, US
Duane Olsen - Hillsborough NC, US
John Groelke - Raleigh NC, US
Reha Azizoglu - Morrisville NC, US
Mitch Hockett - Raleigh NC, US
David Newcomb - Morrisville NC, US
Tobias M. Heineck - Durham NC, US
Joy Parr Drach - Pontiac IL, US

International Classification:

G01N 33/569

US Classification:

4352872

Abstract:

A sample cartridge () for microscopic imaging of a biological sample comprises a body having an end portion () and a pair of generally parallel opposing side edge portions (), a locking edge portion () formed on the body; a carrier removably connected to or permanently connected to the body; and at least one anti-analyte antibody coupled to either the carrier or to the chamber () side wall portion (e.g., at the surface to be imaged, or supporting the sample to be imaged). An XYZ stage () for receiving such a cartridge () is also described.