Robert Lynn Cheek from 6135 Oscar Gammon Rd, Mebane, NC 27302, age 68

License Records

Robert Tines Cheek Md

License #:

14692 - Expired

Category:

Medicine

Issued Date:

Jul 25, 1978

Effective Date:

Dec 1, 1983

Type:

Physician

Us Patents

He4 Monoclonal Antibodies And Methods For Their Use
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US Patent:

7846692, Dec 7, 2010
Filed:

Mar 7, 2008
Appl. No.:

12/044302
Inventors:

Robert L. Cheek - Mebane NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US
Assignee:

Tripath Imaging, Inc. - Burlington NC
International Classification:

C12P 21/04
US Classification:

435 7021, 4241841, 5303871
Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

Glycodelin Monoclonal Antibodies And Methods For Their Use In The Detection Of Ovarian Cancer
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US Patent:

8252904, Aug 28, 2012
Filed:

Mar 5, 2010
Appl. No.:

12/718693
Inventors:

Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Apex NC, US
Assignee:

Tripath Imaging, Inc. - Burlington NC
International Classification:

C07K 16/00
C07K 14/00
C07K 5/00
G01N 33/53
US Classification:

5303871, 5303879, 5303881, 530330, 530324, 530395, 435 71
Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.

Glycodelin Monoclonal Antibodies And Methods For Their Use In The Detection Of Ovarian Cancer
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US Patent:

8476033, Jul 2, 2013
Filed:

Jul 27, 2012
Appl. No.:

13/560080
Inventors:

Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Cary NC, US
Assignee:

TriPath Imaging, Inc. - Burlington NC
International Classification:

G01N 33/00
C07K 16/00
US Classification:

435 792, 435 794, 435 71, 435 72, 5303871, 5303881, 530350, 436 64
Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.

Methods For Identifying Patients With An Increased Likelihood Of Having Ovarian Cancer And Compositions Therefor
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US Patent:

20070212721, Sep 13, 2007
Filed:

Jan 29, 2007
Appl. No.:

11/699229
Inventors:

Timothy Fischer - Raleigh NC, US
Douglas Malinowski - Hillsborough NC, US
Qin He - Raleigh NC, US
Clark Whitehead - Raleigh NC, US
Robert Cheek - Mebane NC, US
Assignee:

TriPath Imaging, Inc. - Burlington NC
International Classification:

C12Q 1/68
G01N 33/574
G06F 19/00
US Classification:

435006000, 435007230, 702019000, 702020000
Abstract:

Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.

Methods For Identifying Patients With An Increased Likelihood Of Having Ovarian Cancer And Compositions Therefor
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US Patent:

20090068690, Mar 12, 2009
Filed:

Oct 30, 2008
Appl. No.:

12/261205
Inventors:

Timothy J. Fischer - Raleigh NC, US
Douglas P. Malinowski - Hillsborough NC, US
Qin He - Raleigh NC, US
Clark M. Whitehead - Raleigh NC, US
Robert L. Cheek - Mebane NC, US
John W. Groelke - Raleigh NC, US
Assignee:

TriPath Imaging, Inc. - Burlington NC
International Classification:

C12Q 1/02
C12Q 1/00
A61B 5/00
A61B 5/055
A61B 10/00
G01N 33/53
US Classification:

435 792, 435 4, 435 71, 435 29, 600300, 600562, 600437, 600410
Abstract:

Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.

Methods For Identifying Patients With An Increased Likelihood Of Having Ovarian Cancer And Compositions Therefor
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US Patent:

20090075307, Mar 19, 2009
Filed:

Oct 30, 2008
Appl. No.:

12/261330
Inventors:

Timothy J. Fischer - Raleigh NC, US
Douglas P. Malinowski - Hillsborough NC, US
Qin He - Raleigh NC, US
Clark M. Whitehead - Raleigh NC, US
Robert L. Cheek - Mebane NC, US
John W. Groelke - Raleigh NC, US
Assignee:

TriPath Imaging, Inc. - Burlington NC
International Classification:

G01N 33/53
C12Q 1/02
G01N 33/68
G01N 33/536
US Classification:

435 792, 435 29, 436 86, 436536
Abstract:

Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.

Matrix Metalloproteinase-7 (Mmp-7) Monoclonal Antibodies And Methods For Their Use In The Detection Of Ovarian Cancer
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US Patent:

20100227335, Sep 9, 2010
Filed:

Mar 5, 2010
Appl. No.:

12/718603
Inventors:

Jeffrey P. Baker - Durham NC, US
Robert L. Cheek - Mebane NC, US
Eric P. Dixon - Cary NC, US
Timothy J. Fischer - Raleigh NC, US
Steven L. Knapp - Apex NC, US
Stephen G. Simkins - Fuquay-Varina NC, US
Clark M. Whitehead - Apex NC, US
Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ
International Classification:

G01N 33/574
C07K 16/18
C12N 5/12
C07K 14/435
C07K 7/08
C07H 21/04
C12P 21/04
G01N 33/53
US Classification:

435 74, 53038826, 5303879, 435346, 530324, 530326, 536 235, 435 7021, 435331, 435 79
Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MMP-7. Monoclonal antibodies having the binding characteristics of an MMP-7 antibody of the invention and monoclonal antibodies that bind to an MMP-7 epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce an MMP-7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed MMP-7 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MMP-7 epitope of a disclosed monoclonal MMP-7 antibody and methods of using these polypeptides in the production of MMP-7 antibodies are also encompassed by the present invention.

He4 Monoclonal Antibodies And Methods For Their Use
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US Patent:

20110038883, Feb 17, 2011
Filed:

Oct 29, 2010
Appl. No.:

12/915200
Inventors:

Robert L. Cheek - Mebane NC, US
Timothy J. Fischer - Raleigh NC, US
John W. Groelke - Raleigh NC, US
Assignee:

TriPath Imaging, Inc - Burlington NC
International Classification:

A61K 39/00
C07K 16/18
C12N 5/16
G01N 33/53
C07K 7/06
C07K 7/08
C07K 14/00
C07H 21/04
C12P 21/06
US Classification:

4241841, 5303882, 435332, 435 71, 530327, 530325, 530326, 536 231, 435 696
Abstract:

Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

Name / Title

Company / Classification

Phones & Addresses

PO Box 51688, Durham, NC 27717

Robert Cheek
Contact, Principal

Cheek, Robert Fine Arts
Business Services at Non-Commercial Site

PO Box 51688, Durham, NC 27717
Durham, NC 27717
(919)4029070, (919)4029412

Medicine Doctors

Robert T. Cheek

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Specialties:

Internal Medicine

Work:

Internal Medicine South Clinic
4110 Outpatient Cir STE 2508, Little Rock, AR 72205
(501)6865545 (phone), (501)6868765 (fax)

Education:

Medical School
University of Arkansas College of Medicine at Little Rock
Graduated: 1976

Procedures:

Cardiac Stress Test
Destruction of Benign/Premalignant Skin Lesions
Vaccine Administration
Nutrition Therapy

Conditions:

Abdominal Hernia
Abnormal Vaginal Bleeding
Acne
Anemia
Atrial Fibrillation and Atrial Flutter

Languages:

English
Spanish

Description:

Dr. Cheek graduated from the University of Arkansas College of Medicine at Little Rock in 1976. He works in Little Rock, AR and specializes in Internal Medicine.

Robert F. Cheek

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Specialties:

Anatomic Pathology & Clinical Pathology

Work:

Boyce & Bynum Pathology Laboratories
200 Portland St, Columbia, MO 65201
(573)8864600 (phone), (573)8864695 (fax)

Education:

Medical School
University of Missouri, Columbia School of Medicine
Graduated: 1990

Languages:

English

Description:

Dr. Cheek graduated from the University of Missouri, Columbia School of Medicine in 1990. He works in Columbia, MO and specializes in Anatomic Pathology & Clinical Pathology.

Robert Tines Cheek

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Specialties:

Internal Medicine
General Practice

Education:

University of Arkansas(1976)

Resumes

Robert Cheek Clover, VA

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Work:

Spuntech Industries

Mar 2014 to 2000
Material Handler/Forklift Operator Gamestop
South Boston, VA
Oct 2009 to Mar 2014
Game Advisor Person Memorial Hospital
Roxboro, NC
Jul 2005 to Apr 2009
Rad Tech 1

Education:

Central Virginia Community College
Lynchburg, VA
2001 to 2005
A.A.S. in Radiologic Technology