Robert O Clarke

US Patent:

7096811, Aug 29, 2006

Filed:

May 18, 2004

Appl. No.:

10/848198

Inventors:

Robert A. Clarke - Poolesville MD, US

Assignee:

Advanced Engineering & Planning Corporation, Inc. - Rockville MD

International Classification:

B63B 25/00

US Classification:

114 72, 114256

Abstract:

The present invention provides an apparatus, method and system for delivery of commercial cargo containers shore side without container terminals. The present invention utilizes containers made autonomous by coupling a container with a detachable propulsion system, having a motor and navigation and steering controls, permitting the rapid, controlled, efficient and safe delivery of cargo containers individually by water. Ballast units, deployment systems and control via remote units are also disclosed. These improvements allow the containers, utilizing their inherent buoyancy, to approach a shore autonomously according to a preplanned or remote controlled route to a specific location and in a specific order of arrival, thereby reducing the number of cargo handlers required, speeding the delivery process to the shore, and eliminating the need for high-technology pier-side equipment. The present invention allows the transfer of cargo at primitive shore sites as well modern pier facilities, and expedites the delivery of such cargo wherever needed.

US Patent:

7320289, Jan 22, 2008

Filed:

Aug 17, 2006

Appl. No.:

11/505307

Inventors:

Robert A. Clarke - Poolesville MD, US

International Classification:

B63B 25/00

US Classification:

114 72, 114256

Abstract:

The present invention provides an apparatus, method and system for delivery of commercial cargo containers shore side without container terminals. The present invention utilizes containers made autonomous by coupling a container with a detachable propulsion system, having a motor and navigation and steering controls, permitting the rapid, controlled, efficient and safe delivery of cargo containers individually by water. Ballast units, deployment systems and control via remote units are also disclosed. These improvements allow the containers, utilizing their inherent buoyancy, to approach a shore autonomously according to a preplanned or remote controlled route to a specific location and in a specific order of arrival, thereby reducing the number of cargo handlers required, speeding the delivery process to the shore, and eliminating the need for high-technology pier-side equipment. The present invention allows the transfer of cargo at primitive shore sites as well modern pier facilities, and expedites the delivery of such cargo wherever needed.

US Patent:

61437379, Nov 7, 2000

Filed:

Jun 21, 1996

Appl. No.:

8/667542

Inventors:

Robert Clarke - Rockville MD
Abdel H. Talebian - Herndon VA
Alem Ghiorghis - Silver Spring MD
Fabio Leonessa - Takoma Park MD
Charles Hammer - Santa Fe NM

Assignee:

Georgetown University - Washington DC

International Classification:

A61K 3157
C07J 3100

US Classification:

514177

Abstract:

The present invention is directed to compounds of formula I ##STR1## wherein the substituents are as defined in the specification. Also disclosed are compositions and method of use of the compounds.

US Patent:

44775385, Oct 16, 1984

Filed:

Feb 17, 1981

Appl. No.:

6/235051

Inventors:

Robert L. Clarke - Riva MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

B32B 04

US Classification:

428656

Abstract:

A coating for nickel/cobalt base alloys used in gas turbine constructions comprises a platinum metal underlayer, an intermediate MCrAlY layer, and a platinum metal overlayer. The platinum type metal is selected from the group consisting of platinum, rhodium, palladium and/or iridium. The MCrAlY material consists of yttrium (Y), aluminum (Al), chromium (Cr) and a balance represented by the letter (M) and selected from the group cobalt, iron and nickel.

US Patent:

50915231, Feb 25, 1992

Filed:

Dec 3, 1990

Appl. No.:

7/620853

Inventors:

Abdolhossen Talebian - Herndon VA
Dianna Green - Falls Church VA
Charles Hammer - Washington DC
Philip Schein - Bryn Mawr PA
Alem Ghiorghis - Washington DC
Robert R. Clarke - Bethesda MD

Assignee:

Georgetown University - Washington DC

International Classification:

A61K 3140
A61K 2100
C07D48714

US Classification:

536 173

Abstract:

The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to supress the growth of cancer cells. The invention also relates to processes for the preparation of the mitomycin derivatives of the invention.

US Patent:

39840352, Oct 5, 1976

Filed:

Jun 13, 1974

Appl. No.:

5/478846

Inventors:

Robert E. Clarke - Bel Air MD

International Classification:

B65D 572

US Classification:

222497

Abstract:

A closure unit for compressible containers and other types of fluid outlets wherein the container is provided with an extension having an opening leading from the container to the extension upon which the closure unit is supported. The closure unit is provided with a fixed stem centrally located of the extension and a separate flexible closed-end sleeve having a central opening through the closed end adapted to overlie the extended portion of the container and the stem, and to be axially movable relative to the stem. The sleeve is provided with a rigid outer side portion and an outer end portion of which at least a portion is provided with a predetermined amount of elasticity. The central opening in the sleeve is slightly less in diameter than the outer end of the stem and when in its outer position will rest lightly on the top of the stem and will flex outwardly to allow the container contents to pass about the stem and out through the opening when pressure is applied to the container, and when the sleeve is in its inward position the sleeve is forced inwardly over the outer end of the stem to provide a definite closure for the opening in the container.

US Patent:

20170007588, Jan 12, 2017

Filed:

May 16, 2016

Appl. No.:

15/155258

Inventors:

- Washington DC, US
Milton L. Brown - Brookeville MD, US
Robert Clarke - Rockville MD, US
Jacqueline Smith - Bowie MD, US

Assignee:

GEORGETOWN UNIVERSITY - Washington DC

International Classification:

A61K 31/4439

Abstract:

Small molecule inhibitors of XBP1 splicing by IRE1α are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

US Patent:

20140088148, Mar 27, 2014

Filed:

Apr 4, 2012

Appl. No.:

14/009969

Inventors:

Sivanesan Dakshanamurthy - Hernon VA, US
Milton L. Brown - Brookeville MD, US
Robert Clarke - Rockville MD, US
Ayesha N. Shahjahan - Haymarket VA, US
Jaqueline Smith - Bowie MD, US

Assignee:

GEORGETOWN UNIVERSITY - Washington DC

International Classification:

C07D 213/32
A61K 31/4439
A61K 45/06
C07D 417/14
C07D 401/14
C07D 405/14
A61K 31/444
C07D 401/04
C07D 417/04

US Classification:

514333, 5462724, 514340, 5462704, 514342, 514341, 514343, 5462684, 546337, 514357, 514337, 546256, 435375

Abstract:

Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.