Robert J Fleming

US Patent:

39579867, May 18, 1976

Filed:

Jul 2, 1973

Appl. No.:

5/375754

Inventors:

Albert A. Carr - Cincinnati OH
Robert W. Fleming - Cincinnati OH
Arthur D. Sill - Cincinnati OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

A01N 900

US Classification:

424248

Abstract:

Novel bis-basic esters and amides of xanthene and xanthone of the formula ##SPC1## Wherein: Z is oxygen or H. sub. 2 ; each of R. sup. 1 and R. sup. 2 is hydrogen, (lower)-alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R. sup. 1 and R. sup. 2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkylpiperazino, or morpholino; Each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms; and each Y is oxygen, or >N--R wherein R is hydrogen or (lower)-alkyl of 1 to 4 carbon atoms; Or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

US Patent:

39624510, Jun 8, 1976

Filed:

Jun 4, 1974

Appl. No.:

5/476331

Inventors:

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Ann Arbor MI

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

A61K 31445

US Classification:

424267

Abstract:

Novel 3,6-bis-basic alkanes of carbazole, their preparation and use for the prevention and inhibition of viral infections are disclosed.

US Patent:

39324567, Jan 13, 1976

Filed:

Jun 16, 1969

Appl. No.:

4/833718

Inventors:

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

C07D20988

US Classification:

260315

Abstract:

Novel bis-basic esters and amides of carbazole of the formula ##SPC1## Wherein: A. each of R. sup. 1 and R. sup. 2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or R. sup. 1 and R. sup. 2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower) alkylpiperazino, or morpholino; B. each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms; C. each Y is oxygen, or N--R wherein R is hydrogen, methyl or ethyl; and D. r. sup. 3 is hydrogen or (lower) primary or secondary alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

US Patent:

41466241, Mar 27, 1979

Filed:

Sep 14, 1970

Appl. No.:

5/072171

Inventors:

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

A61K 31335
A61K 31395
A61K 31445
A61K 31535

US Classification:

42424857

Abstract:

Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an effective quantity of an active ingredient are disclosed herein. The active ingredients are those compounds having the formula ##STR1## wherein A is a straight or branched alkylene chain of from 1 to 6 carbon atoms and each Y is the group (A) ##STR2## wherein R. sup. 1 and R. sup. 2 are each individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or (B) ##STR3## wherein n is a whole integer of 4, 5 or 6 and R. sup. 3 is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl and can be attached to any one of the carbon atoms of the heterocyclic group; or (C) ##STR4## wherein X is oxygen or N--R. sup. 4 and R. sup. 4 is hydrogen or lower alkyl of from 1 to 4 carbon atoms, Or pharmaceutically acceptable acid addition salts of said compounds.

US Patent:

39832481, Sep 28, 1976

Filed:

Aug 6, 1971

Appl. No.:

5/169861

Inventors:

Johann M. Grisar - Cincinnati OH
Arthur D. Sill - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

H61K 3118

US Classification:

424321

Abstract:

Compounds useful as antiviral agents are those of the formula ##SPC1## Wherein each R. sup. 1 is hydrogen or methyl; each n is an integer of 2 to 4; each of R. sup. 2 and R. sup. 3 is alkyl of 3 to 5 carbon atoms or alkenyl of 3 to 5 carbon atoms; or a pharmaceutically acceptable acid addition salt of said base. Pharmaceutical compositions are formed from these compounds with pharmaceutically acceptable carriers.

US Patent:

41088964, Aug 22, 1978

Filed:

Dec 21, 1972

Appl. No.:

5/317247

Inventors:

Laird F. Miller - Loveland OH
Robert W. Fleming - Ann Arbor MI

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

C07C 9710

US Classification:

2605705C

Abstract:

Novel 1,5 and 1,8-bis-basic ketones of anthracene useful for the prevention and inhibition of viral infections are prepared by reacting 1,5 and 1,8 bis(. omega. -haloacyl)anthracenes with a secondary amine.

US Patent:

39324249, Jan 13, 1976

Filed:

Jul 31, 1974

Appl. No.:

5/493271

Inventors:

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Assignee:

Richardson-Merrell Inc. - Wilton CT

International Classification:

C07D20988

US Classification:

26029361

Abstract:

The novel bis-basic ethers of carbazole of the present invention have useful antiviral properties. These new compounds are represented by the formula ##SPC1## Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; and each X is ##EQU1## A. the group -A-N wherein each A is a straight or branched alkylene chain having from 2 to 6 carbon atoms; R and R. sup. 1 are individually hydrogen or lower alkyl having from 1 to 6 carbon atoms; or each set of R and R. sup. 1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino or piperidino; or B. the group ##SPC2## Wherein n is a whole integer from 0 to 2, m is 1 or 2, and R. sup. 2 is hydrogen or lower alkyl having from 1 to 4 carbon atoms. This invention also includes pharmaceutically acceptable acid addition salts of the bases represented by Formula I.

US Patent:

40169286, Apr 12, 1977

Filed:

Dec 26, 1973

Appl. No.:

5/428075

Inventors:

Eugene L. Bartels - Kettering OH
Robert B. Fleming - Scotia NY

Assignee:

General Electric Company - Schenectady NY

International Classification:

F28D 710

US Classification:

165141

Abstract:

A heat exchanger core comprises a plurality of high conductivity expanded metal plates interleaved with a plurality of low conductivity separators configured and aligned to provide mutually isolated fluid flow channels across the expanded metal plates.