Robert A Franco

US Patent:

6376175, Apr 23, 2002

Filed:

Jul 28, 1998

Appl. No.:

09/123728

Inventors:

J. Gordon Foulkes - Huntington Station NY
Franz Leichtfried - Bellerose NY
Christian Pieler - Westbury NY
John R. Stephenson - Rockville Centre NY
Robert Franco - Spencerport NY

Assignee:

OSI Pharmaceuticals, Inc. - Uniondale NY

International Classification:

C12Q 168

US Classification:

435 6, 435 691, 435 911, 4353201, 536 241

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.

US Patent:

6589733, Jul 8, 2003

Filed:

Jun 5, 1995

Appl. No.:

08/463398

Inventors:

J. Gordon Foulkes - Huntington Station NY
Robert Franco - Spencerport NY
Franz Leichtfried - Bellerose NY
Christian Pieler - Westbury NY
John R. Stephenson - Rockville Centre NY

Assignee:

Osi Pharmaceuticals, Inc. - Melville NY

International Classification:

C12Q 168

US Classification:

435 6, 424 91, 435 29

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene of interest, the expression of which is associated with a defined physiological or pathological effect within a multicellular organism. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) specifically transcriptionally modulate expression of the gene of interest, and (c) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell, the binding of a ligand to which ligand binding domain is normally associated with the defined physiological or pathological effect.

US Patent:

20030138773, Jul 24, 2003

Filed:

Mar 25, 1998

Appl. No.:

09/047966

Inventors:

J. GORDON FOULKES - HUNTINGTON STATION NY, US
ROBERT FRANCO - SPENCERPORT NY, US
CHRISTIAN PIELER - WESTBURY NY, US
JOHN R. STEPHENSON - ROCKVILLE CENTRE NY, US

International Classification:

C12Q001/68
G01N033/567
G01N033/53
C12Q001/66
A01K067/00
C12N015/85

US Classification:

435/006000, 435/007210, 435/007600, 435/008000, 435/455000

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene of interest, the expression of which is associated with a defined physiological or pathological effect within a multicellular organism. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) specifically transcriptionally modulate expression of the gene of interest, and (c) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell, the binding of a ligand to which ligand binding domain is normally associated with the defined physiological or pathological effect.

US Patent:

20030166281, Sep 4, 2003

Filed:

Apr 16, 2002

Appl. No.:

10/124113

Inventors:

J. Foulkes - Huntington Station NY, US
Franz Leichtfried - Bellerose NY, US
Christian Pieler - Westbury NY, US
John Stephenson - Rockville Centre NY, US
Robert Franco - Spencerport NY, US

Assignee:

OSI Pharmaceuticals, Inc.

International Classification:

C12N015/85
A61K048/00

US Classification:

435/455000, 514/044000

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.

US Patent:

20080009060, Jan 10, 2008

Filed:

Feb 8, 2007

Appl. No.:

11/704094

Inventors:

J. Foulkes - Huntington Station NY, US
Franz Leichtfried - Bellerose NY, US
Christian Pieler - Westbury NY, US
John Stephenson - Rockville Centre NY, US
Robert Franco - Spencerport NY, US

International Classification:

C12N 5/00

US Classification:

435375000

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.

US Patent:

57765022, Jul 7, 1998

Filed:

Jun 2, 1995

Appl. No.:

8/458691

Inventors:

J. Gordon Foulkes - Huntington Station NY
Robert Franco - Spencerport NY
Franz Leichtfried - Bellerose NY
Christian Pieler - Westbury NY
John R. Stephenson - Rockville Centre NY

Assignee:

Oncogene Science, Inc. - Uniondale NY

International Classification:

C12N 1500
A61K 4900
A61K 3300
A61K 3170

US Classification:

424617

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene of interest, the expression of which is associated with a defined physiological or pathological effect within a multicellular organism. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) specifically transcriptionally modulate expression of the gene of interest, and (c) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell, the binding of a ligand to which ligand binding domain is normally associated with the defined physiological or pathological effect.

US Patent:

56655436, Sep 9, 1997

Filed:

Jun 28, 1994

Appl. No.:

8/267834

Inventors:

J. Gordon Foulkes - Huntington Station NY
Franz Leichtfried - Bellerose NY
Christian Pieler - Westbury NY
John R. Stephenson - Rockville Centre NY
Robert Franco - Spencerport NY

Assignee:

Oncogene Science, Inc. - Uniondale NY

International Classification:

C12Q 168
C12N 1585
C12P 2102

US Classification:

435 6

Abstract:

The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.

US Patent:

D3417190, Nov 30, 1993

Filed:

Sep 23, 1991

Appl. No.:

7/764381

Inventors:

Robert Franco - Deer Park NY

US Classification:

D 4104