Robert S Freedman

US Patent:

20050266393, Dec 1, 2005

Filed:

Sep 30, 2004

Appl. No.:

10/954720

Inventors:

Gregory Baxter - Palo Alto CA, US
Robert Freedman - Beverly Hills CA, US

International Classification:

C12Q001/00
C12N005/02

US Classification:

435004000, 435404000, 435289100

Abstract:

In vitro culture devices and methods are described. The subject methods and devices provide a means whereby cells and/or subcellular material are grown or held in a culture device that maintains the cells and/or subcellular material in a physiologically representative environment, thereby improving the predictive value of toxicity and metabolism assays, and the relevance of experimental results derived from such assays to actual in vivo conditions, processes and outcomes. The culture devices of the invention comprise a fluidic channel connected to or otherwise integrated with at least one chamber, preferably integrated in a chip format. The specific chamber geometry is designed to provide cellular interactions, liquid flow, and liquid residence and other parameter values that correlate with those found in or produced by the corresponding cell, organs or tissues, or components or products thereof, in vivo. Each device comprises at least one chamber and at least one inlet and one outlet port that allow for recirculation of the culture medium. The device will usually include a mechanism for obtaining signals from the cells and culture medium.

US Patent:

20120165067, Jun 28, 2012

Filed:

Sep 21, 2011

Appl. No.:

13/239277

Inventors:

Robert D. Tausworthe - Santa Clara CA, US
Robert H. Freedman - San Francisco CA, US

International Classification:

H04W 88/02

US Classification:

4555561

Abstract:

A mobile telephone includes a television receiver and a pre-loaded advertisement module including stored advertisements and advertisement display instructions. The advertisement display instructions control the display of the stored advertisements as television content is processed by the television receiver.