Robert M Garbaccio

Address:

133 Addison Ln, Lansdale, PA 19446

Phone:

(215)6311416

VIN:

JHLRE48768C022678

Make:

HONDA

Model:

CR-V

Year:

2008

US Patent:

7192949, Mar 20, 2007

Filed:

Apr 24, 2006

Appl. No.:

11/410341

Inventors:

Mark E. Fraley - North Wales PA, US
Robert M. Garbaccio - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 239/70
C07D 401/12
A61K 31/517
A61P 35/00

US Classification:

51421206, 544116, 544230, 544253, 540504, 540460, 540470, 540492, 540575, 5142663, 5142345, 514218, 5142581

Abstract:

The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

7294640, Nov 13, 2007

Filed:

Jan 21, 2005

Appl. No.:

11/040522

Inventors:

Paul J. Coleman - Wallingford PA, US
Robert M. Garbaccio - Lansdale PA, US
Lou Anne Neilson - Sellersville PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/426
C07D 277/22
C07D 277/28
C07D 277/26
C07D 277/24

US Classification:

514365, 548202, 548203, 548204, 548205

Abstract:

The present invention relates to substituted thiazole derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin and MCAK activity, and for inhibiting KSP kinesin and MCAK. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

7329762, Feb 12, 2008

Filed:

Jun 8, 2004

Appl. No.:

10/559857

Inventors:

Mark E. Fraley - North Wales PA, US
Robert M. Garbaccio - Lansdale PA, US
George D. Hartman - Lansdale PA, US
William F. Hoffman - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 207/00
C07D 405/00
C07D 295/00
A01N 43/36
A61K 31/40

US Classification:

548530, 548517, 548537, 548539, 548540, 514422, 514423, 514429

Abstract:

The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

7348440, Mar 25, 2008

Filed:

Jun 12, 2003

Appl. No.:

10/517559

Inventors:

Kenneth L. Arrington - Philadelphia PA, US
Paul J. Coleman - Wallingford PA, US
Christopher D. Cox - Harleysville PA, US
Mark E. Fraley - North Wales PA, US
Robert M. Garbaccio - Lansdale PA, US
George D. Hartman - Lansdale PA, US
William F. Hoffman - Lansdale PA, US
Edward S. Tasber - Norristown PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 207/00
C07D 403/00
C07D 213/00
C07D 401/00
C07D 271/00
C07D 277/20
C07D 261/06
C07D 285/14
C07D 249/08
C07D 231/00
A61K 31/535
A61K 31/497
A01N 43/40
A01N 43/82
A01N 43/80
A01N 43/64
A01N 43/56
A01N 43/36

US Classification:

548538, 5142315, 51425213, 514277, 514326, 514364, 514372, 514378, 514383, 514406, 514423, 544372, 546 1, 546207, 548125, 548202, 548247, 548141, 5482666, 5483641, 548530

Abstract:

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

7465746, Dec 16, 2008

Filed:

Aug 11, 2004

Appl. No.:

10/915743

Inventors:

Paul J. Coleman - Wallingford PA, US
Christopher D. Cox - Harleysville PA, US
Robert M. Garbaccio - Lansdale PA, US
George D. Hartman - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4468

US Classification:

514326, 546187

Abstract:

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

7485649, Feb 3, 2009

Filed:

Jan 5, 2006

Appl. No.:

11/794861

Inventors:

Edward J. Brnardic - Lansdale PA, US
Mark E. Fraley - North Wales PA, US
Robert M. Garbaccio - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4745
C07D 471/06

US Classification:

514287, 546 64

Abstract:

The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.

US Patent:

7608739, Oct 27, 2009

Filed:

Mar 18, 2005

Appl. No.:

10/593504

Inventors:

Robert M. Garbaccio - Lansdale PA, US
Christy M. Olson - Sellersville PA, US
Edward S. Tasber - Norristown PA, US
Maricel Torrent - Lansdale PA, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

C07C 211/00

US Classification:

564305

Abstract:

The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

7622468, Nov 24, 2009

Filed:

Dec 16, 2003

Appl. No.:

10/539531

Inventors:

Mark E. Fraley - North Wales PA, US
Robert M. Garbaccio - Lansdale PA, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/535
C07D 241/022

US Classification:

5142355, 544406

Abstract:

The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.