Robert Lewis Grubbs

US Patent:

7381404, Jun 3, 2008

Filed:

Jul 1, 2003

Appl. No.:

10/611013

Inventors:

Daniel M. Schwartz - San Francisco CA, US
Scott Fraser - LaCanada-Flintridge CA, US
Robert H. Grubbs - South Pasadena CA, US
Justin P. Gallivan - Pasadena CA, US
Changjun Yu - Pasadena CA, US

Assignee:

The Regents of the University of California - Oakland CA
California Institute of Technology - Pasadena CA

International Classification:

A61K 31/74

US Classification:

424 7804, 424 7802, 607 1, 607 88

Abstract:

The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.

US Patent:

7727544, Jun 1, 2010

Filed:

May 9, 2005

Appl. No.:

11/124673

Inventors:

Daniel M. Schwartz - San Francisco CA, US
Chang Jun Yu - Pasadena CA, US
Robert H. Grubbs - Pasadena CA, US
Julia A. Kornfield - Pasadena CA, US
Scott E. Fraser - Lacanada-flintridge CA, US
Matthew S. Mattson - Pasadena CA, US

Assignee:

The Regents of the University of California - Oakland CA
California Institute of Technology - Pasadena CA

International Classification:

A61F 2/00
A61K 31/74

US Classification:

424427, 424 7808

Abstract:

The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.

US Patent:

8298521, Oct 30, 2012

Filed:

May 23, 2008

Appl. No.:

12/126100

Inventors:

Daniel M. Schwartz - San Francisco CA, US
Scott Fraser - Lacanada-flintridge CA, US
Robert H. Grubbs - South Pasadena CA, US
Justin P. Gallivan - Atlanta GA, US
Changjun Yu - Pasadena CA, US

Assignee:

The Regents of the University of California - Oakland CA
California Institute of Technology - Pasadena CA

International Classification:

A61K 31/74

US Classification:

424 7804, 424 7802, 607 1, 607 88

Abstract:

The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.

US Patent:

20160024244, Jan 28, 2016

Filed:

Apr 28, 2015

Appl. No.:

14/698520

Inventors:

Yan XIA - Mountain View CA, US
Benjamin R. SVEINBJORNSSON - Pasadena CA, US
Robert H. GRUBBS - South Pasadena CA, US
Raymond WEITEKAMP - Pasadena CA, US
Garret M. MIYAKE - Altadena CA, US
Victoria PIUNOVA - Altadena CA, US
Christopher Scot DAEFFLER - Pasadena CA, US

International Classification:

C08G 61/12

Abstract:

The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing useful properties. For example, use of one or more wedge group-containing blocks in some block copolymers of the invention significantly inhibits chain entanglement and, thus, the present block copolymers materials provide a class of polymer materials capable of efficient molecular self-assembly to generate a range of structures, such as periodic nanostructures and microstructures. Materials of the present invention include copolymers having one or more wedge group-containing blocks, and optionally for some applications copolymers also incorporating one or more polymer side group-containing blocks. The present invention also provides useful methods of making and using wedge-type block copolymers.