Dennis D. Elsberry - Plymouth MN Chris Christiansen - Oakdale MN Mary M. Morris - Mounds View MN Douglas Owen Hankner - Fridley MN Robert Cushing Hamlen - Edina MN
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61M 2500
US Classification:
604284, 604173, 604 9301
Abstract:
A medical catheter comprising a proximal end having an opening for fluid containing a therapeutic drug, a distal end, the distal end defining at least one opening, and a porous portion covering the opening defined by the distal end. In one embodiment, the medical catheter comprises a proximal end having an opening for fluid containing a therapeutic drug, at least two distal ends. the proximal end connected to the two distal ends with a connector, the distal ends each defining at least, one opening, a diffuser covering the opening of each distal end, and a separate restrictor downstream of the connector and upstream of each distal end to provide substantially equal flow through each distal end. An additional restrictor can also be placed upstream of the connector. In another embodiment, a combination diffuser and restrictor covers the opening of each distal end.
Implantable Medical Device For Assessing Heart Failure State From Mechanical Pulsus Alternans
Tommy D. Bennett - Shoreview MN, US Lawrence J. Mulligan - Andover MN, US Edwin G. Duffin - North Oaks MN, US Robert C. Hamlen - Edina MN, US Wael Abo-Auda - Harriman TN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61B005/04
US Classification:
600513
Abstract:
An implantable heart monitor (IHM) implanted in a patient's body having electrogram (EGM) sense electrodes coupled with EGM sense circuitry to generate sense events upon detection of cardiac depolarizations and a blood pressure measurement transducer disposed in a heart chamber and coupled with blood pressure measurement circuitry operates to assess heart failure state as a function of mechanical pulsus alternans (MPA). MPA episodes are detected, and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.
William Bertrand - Ventura CA, US Robert Hamlen - Edina MN, US Steve May - Minnetonka MN, US Mitchell Solis - Alpharetta GA, US
International Classification:
A61M005/00
US Classification:
604/009000, 604/247000
Abstract:
A valve seat for a ball valve in an adjustable medical valve is described. The valve seat is formed as a cone in a manifold. The cone is formed by rotating a line that intersects a central axis of the valve seat around the central axis. The angle of the intersection between the line and the central axis is doubled to form the included angle of the valve seat. Generally, the narrower the included angle, the better the tolerance of the assembled valve for variations in the spring constant of the pressure regulating spring. Specifically, the present invention has included angles between 0 and 90 degrees with the preferred included angles being between 10 and 40 degrees. A valve embodying the valve seat is also disclosed.
Angiogenesis Mechanism And Method, And Implantable Device
Michael Theodore Beck - Eden Prairie MN, US Deon Bezuidenhout - Cape Town, ZA Kelvin Bonnema - Brooklyn Park MN, US Kimberly A. Chaffin - Woodbury MN, US Neil Davies - Vredehoek, ZA Brian C.A. Fernandes - Roseville MN, US Eric J. Fogt - Maple Grove MN, US Eric A. Grovender - Minneapolis MN, US Robert Cushing Hamlen - Edina MN, US Matthew Jolly - Minneapolis MN, US Eamonn J. McAndrew - County Galway, IE Syamasundar V. Pakala - Blaine MN, US William P. VanAntwerp - Valencia CA, US Peter P. Zilla - Cape Town, ZA Edouard A. Koullick - Golden Valley MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K 9/00 A61K 38/18 A61K 35/12 A61P 3/10
US Classification:
424424, 514 12, 424 931
Abstract:
Various methods and devices are provided for providing therapy to a living body. In one embodiment, an implanted permeable container has living cells provided therein, and various nutrients and/or agents are provided into the container to promote cell life.
Method And System To Define Patient Specific Therapeutic Regimens By Means Of Pharmacokinetic And Pharmacodynamic Tools
William P. Van Antwerp - Valencia CA, US Robert C. Hamlen - Edina MN, US Eric A. Grovender - Minneapolis MN, US
Assignee:
MEDTRONIC, INC. - Minneapolis MN
International Classification:
A61M 5/168 A61K 38/21 A61K 31/7056 A61P 31/14
US Classification:
604503, 424 857, 514 43, 604 66
Abstract:
Methods for treating Hepatitis infections are provided. In one embodiment, an initial dosage of interferon is administered to a patient, and interferon serum levels and viral load data is collected over time. This data can be used to determine patient-specific pharmacokinetic and pharmacodynamic parameters and then construct patient-specific interferon delivery profiles. Patient-specific delivery profiles can then be used to design patient-specific therapeutic regimens.