Robert G Hillman

US Patent:

48681296, Sep 19, 1989

Filed:

Aug 27, 1987

Appl. No.:

7/090026

Inventors:

Ian Gibbons - Menlo Park CA
Robert S. Hillman - Cupertino CA
Channing R. Robertson - Stanford CA

Assignee:

Biotrack Inc. - Mountain View CA

International Classification:

G01N 110
B01L 302

US Classification:

436179

Abstract:

An apparatus for diluting a sample with a diluent, comprising a fixed volume measuring chamber, a fixed volume receiving chamber and fluid receiving relationship to the measuring chamber, a gas vent in the receiving chamber, a stop flow junction between the measuring chamber and the receiving chamber, a sample application site in fluid donating relationship to the measuring chamber, wherein the vertical height difference between the sample application site and the stop flow junction is insufficient to provide a hydrostatic pressure capable of overcoming backpressure at the stop flow junction when sample is applied to the sample application site, and the diluent application site and fluid donating relationship to the measuring chamber. Sample and diluent are added sequentially to the apparatus of the invention without requiring any intervening operations. Various means are provided for restarting flow, which causes diluent to wash the sample into the receiving chamber, where the two can be mixed.

US Patent:

49467956, Aug 7, 1990

Filed:

Aug 18, 1989

Appl. No.:

7/395808

Inventors:

Ian Gibbons - Menlo Park CA
Robert S. Hillman - Cupertino CA
Channing R. Robertson - Stanford CA
Jimmy D. Allen - Los Altos CA

Assignee:

Biotrack, Inc. - Mountain View CA

International Classification:

G01N 110
B01L 302

US Classification:

436179

Abstract:

An apparatus for diluting a sample with a diluent, comprising a fixed volume measuring chamber, a fixed volume receiving chamber and fluid receiving relationship to the measuring chamber, a gas vent in the receiving chamber, a stop flow junction between the measuring chamber and the receiving chamber, a sample application site in fluid donating relationship to the measuring chamber, wherein the vertical height difference between the sample application site and the stop flow junction is insufficient to provide a hydrostatic pressure capable of overcoming backpressure at the stop flow junction when sample is applied to the sample application site, and the diluent application site and fluid donating relationship to the measuring chamber. Sample and diluent are added sequentially to the apparatus of the invention without requiring any intervening operations. Various means are provided for restarting flow, which causes diluent to wash the sample into the receiving chamber, where the two can be mixed.

US Patent:

50770179, Dec 31, 1991

Filed:

Nov 5, 1987

Appl. No.:

7/117791

Inventors:

Michael M. Gorin - Palo Alto CA
Robert S. Hillman - San Carlos CA
Ian Gibbons - Menlo Park CA
Michael E. Cobb - Sunnyvale CA

Assignee:

Biotrack, Inc. - Mountain View CA

International Classification:

B01L 300

US Classification:

422100

Abstract:

A dilution and mixing cartridge comprising a sample application site, a mixing chamber in fluid receiving relationship to the sample application site, a diluent application site in fluid donating relationship to the mixing chamber, a first valve means selectively preventing flow from the diluent application site to the mixing chamber, and a mixture isolating chamber hydrostatically connected to the mixing chamber is provided along with a method for using this cartridge to sequentially dilute a sample with the same or different diluents.