Abstract:
Novel 3,3-diphenylpropylamines of the formula and any stereoisomers thereof; wherein Rrepresents —H or —CH; Rrepresents —CX, —CRX, —CRRX, or —CRRH, wherein X represents halogen, and Rand Rindependently represent —H or —(C-Calkyl), optionally substituted with halogen; Rand Rindependently represent —H, —OCH, —OH, —CONH, —SONH, —F, —Cl, —Br, —I, —CF, or —(C-Calkyl), optionally substituted with one or two —OH, —(C-Calkoxy), —COOH, or —CO—O—(C-Calkyl); and Rand Rindependently represent C-Calkyl, optionally substituted with hydroxyl, wherein Rand Rtogether contain at least three carbon atoms, and wherein Rand Rmay form a ring together with the amine nitrogen; provided that Rcomprises at least one halogen; or a physiologically acceptable acid addition salt thereof; the 3,3-diphenylpropylamines for use as medicaments, use of the 3,3-diphenylpropylamines for the manufacture of specific medicaments, and pharmaceutical compositions comprising the 3,3-diphenylpropylamines. The present invention also includes a method of treatment involving administration of the 3,3-diphenylpropylamines.