Robert W Kester

US Patent:

6528543, Mar 4, 2003

Filed:

Mar 21, 2000

Appl. No.:

09/532506

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Antonio Focella - Wayne NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - North Caldwell NJ
Robert Francis Kester - Hackensack NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

A61K 3117

US Classification:

514594, 514522, 514530, 514542, 514595, 558413, 558417, 560 9, 560 13, 564 47, 564 56

Abstract:

Glucokinase activating compounds of the formula wherein R and R are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R and R are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

US Patent:

6610846, Aug 26, 2003

Filed:

Sep 28, 2000

Appl. No.:

09/675781

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - Houston TX
Robert Francis Kester - Verona NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D23724

US Classification:

544182, 544211, 544224, 544238, 544329, 544336

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

6951945, Oct 4, 2005

Filed:

Jul 9, 2003

Appl. No.:

10/616359

Inventors:

Fred Thomas Bizzarro - Colonia NJ, US
Wendy Lea Corbett - Randolph NJ, US
Joseph Francis Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George William Holland - Houston TX, US
Robert Francis Kester - Verona NJ, US
Paige Erin Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D285/06
C07D285/12
C07D277/04
C07D275/02

US Classification:

548127, 548128, 548134, 548139, 548195, 548214

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

7223868, May 29, 2007

Filed:

Apr 4, 2005

Appl. No.:

11/098717

Inventors:

Fred Thomas Bizzarro - Colonia NJ, US
Wendy Lea Corbett - Randolph NJ, US
Joseph Francis Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George William Holland - Houston TX, US
Robert Francis Kester - Verona NJ, US
Paige Erin Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 213/75
C07D 213/84

US Classification:

546289, 546297, 546309, 546310

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

7741327, Jun 22, 2010

Filed:

Mar 9, 2009

Appl. No.:

12/400065

Inventors:

Steven Joseph Berthel - Mendham Township NJ, US
John A Brinkman - West Caldwell NJ, US
Stuart Hayden - Manalapan NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
Robert Francis Kester - West Orange NJ, US
Lee Apostle McDermott - East Windsor NJ, US
Yimin Qian - Wayne NJ, US
Ramakanth Sarabu - Towaco NJ, US
Nathan Robert Scott - Livingston NJ, US
Jefferson Wright Tilley - North Caldwell NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 31/497
A61K 31/4439
A61K 31/433
A61K 31/428
A61K 31/426
A61K 31/423
A61K 31/421
A61K 31/4155
C07D 403/12
C07D 401/12
C07D 285/08
C07D 277/82
C07D 277/38
C07D 263/54
C07D 263/48
C07D 231/56
C07D 231/38

US Classification:

51425505, 514343, 514361, 514367, 514371, 514375, 514376, 514407, 544405, 5462787, 548128, 548163, 548195, 548217, 548229, 5483611, 5483641, 5483644, 5483657

Abstract:

Provided herein are compounds of the formula (I):.

US Patent:

7803816, Sep 28, 2010

Filed:

Sep 25, 2006

Appl. No.:

11/526523

Inventors:

Steven Joseph Berthel - Mendham Township NJ, US
Shawn David Erickson - Leonia NJ, US
Nader Fotouhi - Basking Ridge NJ, US
Robert Francis Kester - West Orange NJ, US
Kyungjin Kim - Livingston NJ, US
Steven Gregory Mischke - Florham Park NJ, US
Yimin Qian - Wayne NJ, US
Kshitij Chhabilbhai Thakkar - Clifton NJ, US
Jefferson Wright Tilley - North Caldwell NJ, US
Hong Wang - Nutley NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 31/454
C07D 403/02

US Classification:

514322, 546199

Abstract:

Provided herein are compounds of the formula (I):.

US Patent:

8258134, Sep 4, 2012

Filed:

Mar 9, 2009

Appl. No.:

12/400319

Inventors:

Steven Joseph Berthel - Mendham Township NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
Robert Francis Kester - West Orange NJ, US
Lee Apostle McDermott - East Windsor NJ, US
Yimin Qian - Wayne NJ, US
Ramakanth Sarabu - Towaco NJ, US
Nathan Robert Scott - Livingston NJ, US
Jefferson Wright Tilley - North Caldwell NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 401/06
C07D 401/14
C07D 237/32
C07D 237/10
A61K 31/501
A61K 31/502
A61P 5/50

US Classification:

514247, 51425205, 51425204, 51425203, 51425202, 514248, 544238, 544237, 544224

Abstract:

Provided herein are compounds of the formula (I):.

US Patent:

20070203207, Aug 30, 2007

Filed:

Apr 23, 2007

Appl. No.:

11/789105

Inventors:

Fred Bizzarro - Colonia NJ, US
Wendy Corbett - Randolph NJ, US
Joseph Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George Holland - Houston TX, US
Robert Kester - Verona NJ, US
Paige Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

International Classification:

A61K 31/425
C07C 211/00
C07C 211/01
C07C 311/00
C07D 277/00

US Classification:

514365000, 548199000, 562837000, 564001000, 564366000

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.