Robert M Kester

US Patent:

6433188, Aug 13, 2002

Filed:

Dec 4, 2001

Appl. No.:

10/006005

Inventors:

Wendy Lea Corbett - Randolph NJ 07869
Joseph Samuel Grimsby - Morganville NJ 07751
Nancy-Ellen Haynes - Cranford NJ 07016
Robert Francis Kester - West Orange NJ 07052
Paige Erin Mahaney - West Orange NJ 07052
Ramakanth Sarabu - Pine Brook NJ 07058

International Classification:

C07D26358

US Classification:

549 32, 549467, 548330

Abstract:

Glucokinase activating amides as herein disclosed are useful for increasing insulin secretion in the treatment of type II diabetes.

US Patent:

6441184, Aug 27, 2002

Filed:

Dec 4, 2001

Appl. No.:

10/006168

Inventors:

Wendy Lea Corbett - Randolph NJ
Joseph Samuel Grimsby - Morganville NJ
Nancy-Ellen Haynes - Cranford NJ
Robert Francis Kester - West Orange NJ
Paige Erin Mahaney - West Orange NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffmann-LA Roche Inc. - Nutley NJ

International Classification:

C07D27776

US Classification:

548161, 548222, 5483074

Abstract:

Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.

US Patent:

6448399, Sep 10, 2002

Filed:

Dec 4, 2001

Appl. No.:

10/007091

Inventors:

Wendy Lea Corbett - Randolph NJ
Joseph Samuel Grimsby - Morganville NJ
Nancy-Ellen Haynes - Cranford NJ
Robert Francis Kester - West Orange NJ
Paige Erin Mahaney - West Orange NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D25310

US Classification:

544183, 544283, 544353, 546152, 564155

Abstract:

Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.

US Patent:

6486184, Nov 26, 2002

Filed:

Jul 13, 2001

Appl. No.:

09/905152

Inventors:

Robert Francis Kester - West Orange NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D21302

US Classification:

514352, 514371, 546309, 548192

Abstract:

Substituted benzene acetamide compounds which are glucokinase activators and pharmaceutically acceptable salts thereof.

US Patent:

6528543, Mar 4, 2003

Filed:

Mar 21, 2000

Appl. No.:

09/532506

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Antonio Focella - Wayne NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - North Caldwell NJ
Robert Francis Kester - Hackensack NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

A61K 3117

US Classification:

514594, 514522, 514530, 514542, 514595, 558413, 558417, 560 9, 560 13, 564 47, 564 56

Abstract:

Glucokinase activating compounds of the formula wherein R and R are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R and R are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

US Patent:

6545155, Apr 8, 2003

Filed:

Dec 4, 2001

Appl. No.:

10/006170

Inventors:

Wendy Lea Corbett - Randolph NJ
Joseph Samuel Grimsby - Morganville NJ
Nancy-Ellen Haynes - Cranford NJ
Robert Francis Kester - West Orange NJ
Paige Erin Mahaney - West Orange NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D21538

US Classification:

546159, 546162, 544183, 544253, 544292, 544356

Abstract:

Glucokinase activating amides useful for increasing insulin secretion in the treatment of type II diabetes are disclosed.

US Patent:

6608218, Aug 19, 2003

Filed:

Jun 25, 2002

Appl. No.:

10/179717

Inventors:

Robert Francis Kester - West Orange NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D30902

US Classification:

549419, 564155

Abstract:

Substituted benzene acetamide compounds and pharmaceutically acceptable salts thereof are useful as glucokinase activators.

US Patent:

6610846, Aug 26, 2003

Filed:

Sep 28, 2000

Appl. No.:

09/675781

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - Houston TX
Robert Francis Kester - Verona NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D23724

US Classification:

544182, 544211, 544224, 544238, 544329, 544336

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.