Robert L Kwiatkowski

US Patent:

20030119020, Jun 26, 2003

Filed:

Jul 17, 2002

Appl. No.:

10/197189

Inventors:

Priscilla Stevens - Evanston IL, US
David Kelso - Wilmette IL, US
Victor Lyamichev - Madison WI, US
Jeff Hall - Madison WI, US
Bruce Neri - Madison WI, US
Robert Kwiatkowski - Verona WI, US
Lloyd Smith - Madison WI, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

The present invention relates to systems, compositions, and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for attaching nucleic acids to solid supports and modifying nucleic acids. For example, in some embodiments, the 5′ nuclease activity of a cleavage agent is used to cleave a cleavage structure formed on the solid support, the occurrence of the cleavage event indicating the presence of specific nucleic acid sequences.

US Patent:

20030143585, Jul 31, 2003

Filed:

Oct 11, 2002

Appl. No.:

10/269222

Inventors:

Priscilla Stevens - Evanston IL, US
David Kelso - Wilmette IL, US
Victor Lyamichev - Madison WI, US
Jeff Hall - Madison WI, US
Bruce Neri - Madison WI, US
Robert Kwiatkowski - Verona WI, US
Lloyd Smith - Madison WI, US

Assignee:

Northwestern University - Evanston IL

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

The present invention relates to systems, compositions, and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for attaching nucleic acids to solid supports and modifying nucleic acids. For example, in some embodiments, the 5′ nuclease activity of a cleavage agent is used to cleave a cleavage structure formed on the solid support, the occurrence of the cleavage event indicating the presence of specific nucleic acid sequences.