Robert Dellino Leboeuf

US Patent:

55232906, Jun 4, 1996

Filed:

May 10, 1994

Appl. No.:

8/240802

Inventors:

Robert D. LeBoeuf - Birmingham AL
J. Edwin Blalock - Mountain Brook AL
Kenneth L. Bost - Birmingham AL

Assignee:

University of Alabama at Birmingham Research Foundation - Birmingham AL

International Classification:

C07K 1452
C07K 1624
A61K 3819

US Classification:

514 21

Abstract:

Mammalian pituitary discovered anti-proliferation factor that inhibits in vitro cellular proliferation of lymphoid, neuroendocrine and neural cells but not of fibroblast or endothelial cells. The present invention is directed to this antiproliferation factor which has been named suppressin and is a protein of Mr 63,000, sensitive to reduction and has a pI of 8. 1. Suppressin is provided as a cell free preparation or in homogeneous form. The invention provides methods to purify suppressin, antibodies against suppressin and their use recombinant DNA molecules encoding suppressin, and pharmaceutical compositions for inducing regression or inhibiting growth of tumor or cancel cells and autoimmune diseases.

US Patent:

58175016, Oct 6, 1998

Filed:

Aug 13, 1996

Appl. No.:

8/696349

Inventors:

Robert D. Leboeuf - Homewood AL

Assignee:

UAB Research Foundation - Birmingham AL

International Classification:

C12N 121
C12N 510
C12N 1516
C12N 1563

US Classification:

43525233

Abstract:

A unique gene sequence encoding a suppressin protein has been isolated. Using recombinant DNA techniques, the suppressin protein may be produced in useful quantities. Methods for preparing the gene sequence and the gene product are disclosed. Also provided are novel plasmids and host cells.